Binding of gossypol derivatives to human serum albumin.
Binding of gossypol derivatives to human serum albumin.
复制标题
棉酚衍生物与人血清白蛋白的结合。
DOI：
10.1002/jps.2600770311
复制
发表时间：
1988
影响因子：
3.8
通讯作者：
VanderJagt,DL
中科院分区：
文献类型：
--
作者：
Royer,RE;Kibirige,M;Tafoya,CR;Deck,LM;VanderJagt,DL
In light of our previous finding that gossypol competes effectively with bilirubin for the high affinity bilirubin binding site on human serum albumin, a study of the binding to albumin of four gossypol derivatives was undertaken. The derivatives are compounds in which the aldehyde groups of gossypol are converted to nitriles and the periphenolic groups are acylated with acetyl, propionyl, butyryl, or valeryl groups. These periacylated gossylic nitriles bind to the high affinity bilirubin binding site on human serum albumin, but with dissociation constants ~30 times greater than that of gossypol. The gossypol derivatives also bind to another site on albumin, but with dissociation constants ~6 times greater than those for the bilirubin site. This second site has been identified as the major drug binding site in domain III.
