The Revised National Alzheimer's Coordinating Center's Neuropathology Form-Available Data and New Analyses
The Revised National Alzheimer's Coordinating Center's Neuropathology Form-Available Data and New Analyses
复制标题
DOI：
10.1093/jnen/nly049
复制
发表时间：
2018-08-01
影响因子：
3.2
通讯作者：
Nelson, Peter T.
中科院分区：
文献类型：
--
作者：
Besser, Lilah M.;Kukull, Walter A.;Nelson, Peter T.
神经病理学评估仍然是确定衰老相关神经退行性疾病的存在和严重程度的金标准。美国阿尔茨海默病中心(ADC)的研究人员致力于人类大脑的研究已有30年之久，他们的目标是实现新的研究突破。国家阿尔茨海默病协调中心(NACC)促进了39个当前和过去的ADC之间的协调和共享，该中心收集、审计ADC得出的数据，并应要求将其支付给调查人员。在过去的几十年里，疾病定义得到了修订，同时收集的数据在粒度和多模式方面也出现了戏剧性的扩张。NACC数据库现在包括认知测试分数、合并症、服药史、神经成像和基因组学链接。相对而言，在阿尔茨海默病、额颞叶变性(FTLD)的神经病理学诊断方面的最新进展，以及对认知障碍和痴呆的血管贡献，促使所有ADC完成了2014年NACC神经病理学表格的更新。新的焦点包括脑血管疾病(包括动脉硬化、微出血和微梗塞)、海马硬化症、TDP-43和FTLD。在这里，我们提供总结数据和分析，以说明使用NACC神经病理学数据集进行假设检验和生成新假设的可能性，该数据集代表了全球研究人员免费获得的精心管理的神经病理信息的最大多中心数据库之一。
Neuropathologic evaluation remains the gold standard for determining the presence and severity of aging-related neurodegenerative diseases. Researchers at U.S. Alzheimer's Disease Centers (ADCs) have worked for >30 years studying human brains, with the goals of achieving new research breakthroughs. Harmonization and sharing among the 39 current and past ADCs is promoted by the National Alzheimer's Coordinating Center (NACC), which collects, audits, and disburses ADC-derived data to investigators on request. The past decades have witnessed revised disease definitions paired with dramatic expansion in the granularity and multimodality of the collected data. The NACC database now includes cognitive test scores, comorbidities, drug history, neuroimaging, and links to genomics. Relatively, recent advances in the neuropathologic diagnoses of Alzheimer's disease, frontotemporal lobar degeneration (FTLD), and vascular contributions to cognitive impairment and dementia catalyzed a 2014 update to the NACC Neuropathology Form completed by all ADCs. New focal points include cerebrovascular disease (including arteriolosclerosis, microbleeds, and microinfarcts), hippocampal sclerosis, TDP-43, and FTLD. Here, we provide summary data and analyses to illustrate the potential for both hypothesis-testing and also generating new hypotheses using the NACC Neuropathology data set, which represents one of the largest multi-center databases of carefully curated neuropathologic information that is freely available to researchers worldwide.