Crosslinked hydrogels for tympanic membrane repair.
Crosslinked hydrogels for tympanic membrane repair.
复制标题
用于鼓膜修复的交联水凝胶。
DOI：
10.1016/j.otohns.2006.02.040
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Prestwich,GlennD
中科院分区：
文献类型：
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作者：
Park,AlbertH;Hughes,CaseyW;Jackson,Adrienne;Hunter,Lisa;McGill,Lawrence;Simonsen,SaraEllis;Alder,StephenC;Shu,XiaoZheng;Prestwich,GlennD
问题：提供一种更便宜、更方便的治疗鼓膜穿孔（TMPs）的方案。方法：制备Carbylan-SX、gelylan - dtph - pegda （GX）、Carbylan-S/ gelylan - dtph (Carbylan-GSX)（注射和海绵）、Gelfoam、epifilum、交联硫酸硫酸软骨素（CS-DTPH-PEGDA [CS-SX]）等材料进行TMP修复的比较。Hartley染色豚鼠（Elm Hill）接受双侧鼓膜切开术，左1耳作为对照，另1耳用上述材料之一治疗。结果：Carbylan-GSX（可注射和海绵）、凝胶泡沫与生理盐水、CS-SX的TMP闭合时间最短。外膜、卡比兰和明胶制剂导致闭合率与对照组相似。根据中性粒细胞、淋巴细胞、上皮细胞计数和纤维化程度，与对照组和其他材料相比，CS-SX显示出明显的炎症反应。结论：本研究表明，在急性TMP豚鼠模型中，与明胶泡沫相比，Carbylan-GSX作为一种促进TMP闭合的材料是有效的。
PROBLEM:To provide a less expensive and more convenient protocol for the treatment of tympanic membrane perforations (TMPs).METHODS:Several materials were prepared and compared for TMP repair including Carbylan-SX, Gelatin-DTPH-PEGDA (GX), Carbylan-S/Gelatin-DTPH (Carbylan-GSX) (injectable and sponge), Gelfoam, Epifilm, and crosslinked thiolated chondroitin sulfate (CS-DTPH-PEGDA [CS-SX]). Hartley pigmented guinea pigs (Elm Hill) underwent bilateral myringotomy with 1 ear left as a control and the other treated with one of the previously mentioned materials.RESULTS:Carbylan-GSX (injectable and sponge), Gelfoam with saline, and CS-SX had the shortest time for TMP closure. Epifilm, Carbylan, and gelatin preparations resulted in closure rates similar to controls. CS-SX showed a marked inflammatory reaction compared with controls and other materials based on neutrophil, lymphocyte, epitheloid counts, and degree of fibrosis.CONCLUSIONS:This study shows the validity of Carbylan-GSX compared with Gelfoam as a material to promote TMP closure in an acute TMP guinea pig model.