RELATIONSHIP OF MOTOR SYMPTOMS TO INTELLECTUAL DEFICITS IN PARKINSON DISEASE
RELATIONSHIP OF MOTOR SYMPTOMS TO INTELLECTUAL DEFICITS IN PARKINSON DISEASE
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DOI：
10.1212/wnl.32.2.133
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发表时间：
1982-01-01
期刊：
影响因子：
9.9
通讯作者：
WEBSTER, DD
中科院分区：
文献类型：
--
作者：
MORTIMER, JA;PIROZZOLO, FJ;WEBSTER, DD
我们对50例特发性帕金森病患者进行了运动和神经心理测试，以确定运动症状的严重程度是否与神经心理缺陷的程度相关。在评估视觉空间推理和精神运动速度的测试中，运动迟缓的严重程度与受损的表现之间发现了显著的相关性。在空间定向记忆测试中，更严重的震颤与更好的表现相关。在控制年龄、发病年龄和自评抑郁时，这些关系仍然存在。认知障碍可能是由引起运动症状的皮层下病变引起的。
Patients (50) with idiopathic Parkinson''s disease were studied with motor and neuropsychologic tests to ascertain whether the severity of motor symptoms was associated with the degree of neuropsychologic deficit. Significant correlations were found between the severity of bradykinesia and impaired performance on tests assessing visual-spatial reasoning and psychomotor speed. More severe tremor was associated with better performance on a spatial orientation memory test. These relationships remained when age, age at onset and self-rated depression were controlled. Cognitive impairment may result from the same subcortical lesions that cause motor symptoms.