Magnetic resonance imaging in late-life depression: vascular and glucocorticoid cascade hypotheses
Magnetic resonance imaging in late-life depression: vascular and glucocorticoid cascade hypotheses
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DOI：
10.1192/bjp.bp.111.105361
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发表时间：
2012-07-01
影响因子：
10.5
通讯作者：
Ebmeier, Klaus P.
中科院分区：
文献类型：
--
作者：
Sexton, Claire E.;Le Masurier, Marisa;Ebmeier, Klaus P.
BackgroundLate life depression is a common and heterogeneous illness，associated with structural abnormalities in both grey and白色matter.AimsTo examine the relationship between age at onset and magnetic resonance imaging（MRI）measures of grey and白色matter to establish whether they support particular hypotheses about the anatomy and aetiology of network disruption in late life depression.MethodWe studied 36 participants with late life depression.使用T1加权MRI检查灰质，并使用基于体素的形态学进行分析。海马自动分割和体积和形状进行分析。白色问题进行了检查，采用扩散张量成像和分析，使用基于空间statistics.ResultsLater年龄在发病显着相关的分数各向异性减少广泛的管道，特别是前丘脑辐射和上级纵束。发病年龄越早，双侧海马体积相对于全脑体积标准化后越小。然而，使用海马形状分析或基于体素的morphometry.ConclusionsOverall，结果是兼容的血管假说，并提供了一些支持的糖皮质激素级联假说的相关性检测。
BackgroundLate-life depression is a common and heterogeneous illness, associated with structural abnormalities in both grey and white matter.AimsTo examine the relationship between age at onset and magnetic resonance imaging (MRI) measures of grey and white matter to establish whether they support particular hypotheses regarding the anatomy and aetiology of network disruption in late-life depression.MethodWe studied 36 participants with late-life depression. Grey matter was examined using T-1-weighted MRI and analysed using voxel-based morphometry. The hippocampus was automatically segmented and volume and shape analysis performed. White matter was examined using diffusion tensor imaging and analysed using tract-based spatial statistics.ResultsLater age at onset was significantly associated with reduced fractional anisotropy of widespread tracts, in particular the anterior thalamic radiation and superior longitudinal fasciculus. Earlier age at onset was associated with reduced hippocampal volume normalised to whole brain size bilaterally. However, no significant correlations were detected using hippocampal shape analysis or voxel-based morphometry.ConclusionsOverall, the results were compatible with the vascular hypothesis, and provided some support for the glucocorticoid cascade hypothesis.