The strong MRI relaxivity of paramagnetic nanoparticles.

The strong MRI relaxivity of paramagnetic nanoparticles.
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DOI：
10.1021/jp8012706
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发表时间：
2008-04
期刊：
The journal of physical chemistry. B
影响因子：
--
通讯作者：
G. Xing;Hui Yuan;Rui He;Xueyun Gao;Long Jing;Feng Zhao;Z. Chai;Yuliang Zhao
G. Xing;Hui Yuan;Rui He;Xueyun Gao;Long Jing;Feng Zhao;Z. Chai;Yuliang Zhao
中科院分区：
其他
文献类型：
--
作者：
G. Xing;Hui Yuan;Rui He;Xueyun Gao;Long Jing;Feng Zhao;Z. Chai;Yuliang Zhao

文献摘要

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我们开发了一种合成Gd@C82(OH)22+/-2顺磁性纳米颗粒的方法。这种纳米颗粒具有有序的微观结构，在体外/体内具有较强的MRI质子弛豫。与商业Gd-DTPA相比，在体外获得了具有有序微观结构的Gd@C82(OH)22+/-2纳米颗粒的12倍MRI弛豫度。较小的Gd@C82(OH)22+/-2纳米颗粒，约为65nm，可以很容易地逃避体内RES的摄取；这为它们的临床应用打开了大门。
We developed a method to synthesize paramagnetic nanoparticles of Gd@C82(OH)22+/-2. Such nanoparticles are with ordered microstructures and have strong MRI proton relaxation in vitro/vivo. Compared with commercial Gd-DTPA, a 12x MRI relaxivity of Gd@C82(OH)22+/-2 nanoparticles with ordered microstructures was achieved in vitro. The small Gd@C82(OH)22+/-2 nanoparticles, approximately 65nm, could easily escape the RES uptake in vivo; this opens the door for their clinical applications.