The role of adult tissue-derived stem cells in chronic leg ulcers: a systematic review focused on tissue regeneration medicine
The role of adult tissue-derived stem cells in chronic leg ulcers: a systematic review focused on tissue regeneration medicine
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DOI：
10.1111/iwj.12499
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发表时间：
2016-12-01
影响因子：
3.1
通讯作者：
Serra, Raffaele
中科院分区：
文献类型：
--
作者：
Amato, Bruno;Compagna, Rita;Serra, Raffaele
伤口愈合是一个复杂的过程，慢性伤口的不同步骤可能会受到损害。慢性腿部溃疡是一种特殊类型的不愈合伤口，是西方国家发病率和公共成本的重要原因。由于它们在常规治疗后经常复发，并且由于人口老龄化而患病率不断增加，因此需要新的方法。在过去的十年中，研究一直集中在创新的治疗策略上，包括基于干细胞的疗法。在最初对胚胎多能细胞产生兴趣之后，由于伦理问题，人们对几种不同类型的成体干细胞进行了研究。在体外和体内研究中，特定类型的成体干细胞在组织愈合方面表现出很高的潜力。本综述的目的是清楚地报告组织再生医学的最新见解，特别是慢性腿部溃疡。
Wound healing is an articulated process that can be impaired in different steps in chronic wounds. Chronic leg ulcers are a special type of non-healing wounds that represent an important cause of morbidity and public cost in western countries. Because of their common recurrence after conventional managements and increasing prevalence due to an ageing population, newer approaches are needed. Over the last decade, the research has been focused on innovative treatment strategies, including stem-cell-based therapies. After the initial interest in embryonic pluripotent cells, several different types of adult stem cells have been studied because of ethical issues. Specific types of adult stem cells have shown a high potentiality in tissue healing, in both in vitro and in vivo studies. Aim of this review is to clearly report the newest insights on tissue regeneration medicine, with particular regard for chronic leg ulcers.