Reshaping preoperative treatment of pancreatic cancer in the era of precision medicine.
Reshaping preoperative treatment of pancreatic cancer in the era of precision medicine.
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精准医学时代胰腺癌术前治疗的重塑。
DOI：
10.1016/j.annonc.2020.11.013
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Golan T
中科院分区：
文献类型：
--
作者：
Casolino R;Braconi C;Malleo G;Paiella S;Bassi C;Milella M;Dreyer SB;Froeling FEM;Chang DK;Biankin AV;Golan T
本文综述了胰腺癌术前治疗策略的最新证据，并讨论了非转移性疾病迫切需要个性化治疗方法的理由。胰腺癌的分子多样性及其对预后和治疗反应的影响，加上“全能”治疗对患者结局的显著影响的失败，需要向基因组驱动方法的范式转变。这在术前、潜在可治愈的情况下尤其重要，在这种情况下，个性化治疗分配具有降低胰腺癌死亡率的巨大潜力。胰腺癌的分子多样性需要向基因组驱动的治疗方法转变。未选择的治疗策略在早期胰腺癌中仅显示出有限的疗效。非转移性疾病的个性化治疗有可能降低胰腺癌死亡率。实施术前临床研究以丰富潜在的预后/预测生物标志物是至关重要的。新的治疗发展模式是必要的，以加速胰腺癌护理和研究的进展。
This review summarises the recent evidence on preoperative therapeutic strategies in pancreatic cancer and discusses the rationale for an imminent need for a personalised therapeutic approach in non-metastatic disease. The molecular diversity of pancreatic cancer and its influence on prognosis and treatment response, combined with the failure of ‘all-comer’ treatments to significantly impact on patient outcomes, requires a paradigm shift towards a genomic-driven approach. This is particularly important in the preoperative, potentially curable setting, where a personalised treatment allocation has the substantial potential to reduce pancreatic cancer mortality. Molecular diversity of pancreatic cancer requires a paradigm shift towards a genomic-driven therapeutic approach. Unselected treatment strategies demonstrate only limited efficacy in early-stage pancreatic cancer. Personalised treatment in non-metastatic disease has potential to reduce pancreatic cancer mortality. It is fundamental to implement preoperative clinical studies enriched for potential prognostic/predictive biomarkers. Novel models of therapeutic development are warranted to accelerate progress in pancreatic cancer care and research.
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影响因子：
5
作者：
Cros, Jerome;Raffenne, Jerome;Pote, Nicolas
通讯作者：
Pote, Nicolas
影响因子：
29.4
作者：
Dreyer SB;Upstill-Goddard R;Paulus-Hock V;Paris C;Lampraki EM;Dray E;Serrels B;Caligiuri G;Rebus S;Plenker D;Galluzzo Z;Brunton H;Cunningham R;Tesson M;Nourse C;Bailey UM;Jones M;Moran-Jones K;Wright DW;Duthie F;Oien K;Evers L;McKay CJ;McGregor GA;Gulati A;Brough R;Bajrami I;Pettitt S;Dziubinski ML;Candido J;Balkwill F;Barry ST;Grützmann R;Rahib L;Glasgow Precision Oncology Laboratory,;Australian Pancreatic Cancer Genome Initiative;Johns A;Pajic M;Froeling FEM;Beer P;Musgrove EA;Petersen GM;Ashworth A;Frame MC;Crawford HC;Simeone DM;Lord C;Mukhopadhyay D;Pilarsky C;Tuveson DA;Cooke SL;Jamieson NB;Morton JP;Sansom OJ;Bailey PJ;Biankin AV;Chang DK
通讯作者：
Chang DK
影响因子：
2.4
作者：
Baek, Hae Woon;Park, Min Jee;Park, In Ae
通讯作者：
Park, In Ae
影响因子：
64.8
作者：
Biankin, Andrew V.;Waddell, Nicola;Kassahn, Karin S.;Gingras, Marie-Claude;Muthuswamy, Lakshmi B.;Johns, Amber L.;Miller, David K.;Wilson, Peter J.;Patch, Ann-Marie;Wu, Jianmin;Chang, David K.;Cowley, Mark J.;Gardiner, Brooke B.;Song, Sarah;Harliwong, Ivon;Idrisoglu, Senel;Nourse, Craig;Nourbakhsh, Ehsan;Manning, Suzanne;Wani, Shivangi;Gongora, Milena;Pajic, Marina;Scarlett, Christopher J.;Gill, Anthony J.;Pinho, Andreia V.;Rooman, Ilse;Anderson, Matthew;Holmes, Oliver;Leonard, Conrad;Taylor, Darrin;Wood, Scott;Xu, Qinying;Nones, Katia;Fink, J. Lynn;Christ, Angelika;Bruxner, Tim;Cloonan, Nicole;Kolle, Gabriel;Newell, Felicity;Pinese, Mark;Mead, R. Scott;Humphris, Jeremy L.;Kaplan, Warren;Jones, Marc D.;Colvin, Emily K.;Nagrial, Adnan M.;Humphrey, Emily S.;Chou, Angela;Chin, Venessa T.;Chantrill, Lorraine A.;Mawson, Amanda;Samra, Jaswinder S.;Kench, James G.;Lovell, Jessica A.;Daly, Roger J.;Merrett, Neil D.;Toon, Christopher;Epari, Krishna;Nguyen, Nam Q.;Barbour, Andrew;Zeps, Nikolajs;Kakkar, Nipun;Zhao, Fengmei;Wu, Yuan Qing;Wang, Min;Muzny, Donna M.;Fisher, William E.;Brunicardi, F. Charles;Hodges, Sally E.;Reid, Jeffrey G.;Drummond, Jennifer;Chang, Kyle;Han, Yi;Lewis, Lora R.;Dinh, Huyen;Buhay, Christian J.;Beck, Timothy;Timms, Lee;Sam, Michelle;Begley, Kimberly;Brown, Andrew;Pai, Deepa;Panchal, Ami;Buchner, Nicholas;De Borja, Richard;Denroche, Robert E.;Yung, Christina K.;Serra, Stefano;Onetto, Nicole;Mukhopadhyay, Debabrata;Tsao, Ming-Sound;Shaw, Patricia A.;Petersen, Gloria M.;Gallinger, Steven;Hruban, Ralph H.;Maitra, Anirban;Iacobuzio-Donahue, Christine A.;Schulick, Richard D.;Wolfgang, Christopher L.;Morgan, Richard A.;Lawlor, Rita T.;Capelli, Paola;Corbo, Vincenzo;Scardoni, Maria;Tortora, Giampaolo;Tempero, Margaret A.;Mann, Karen M.;Jenkins, Nancy A.;Perez-Mancera, Pedro A.;Adams, David J.;Largaespada, David A.;Wessels, Lodewyk F. A.;Rust, Alistair G.;Stein, Lincoln D.;Tuveson, David A.;Copeland, Neal G.;Musgrove, Elizabeth A.;Scarpa, Aldo;Eshleman, James R.;Hudson, Thomas J.;Sutherland, Robert L.;Wheeler, David A.;Pearson, John V.;McPherson, John D.;Gibbs, Richard A.;Grimmond, Sean M.
通讯作者：
Grimmond, Sean M.
DOI：
10.1038/s41571-018-0002-6
发表时间：
2018-06
期刊：
Nature reviews. Clinical oncology
影响因子：
--
作者：
Berger MF;Mardis ER
通讯作者：
Mardis ER