Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women
Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women
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DOI：
10.1093/ajcn/87.3.734
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发表时间：
2008-03-01
影响因子：
7.1
通讯作者：
Zhang, Shumin M.
中科院分区：
文献类型：
--
作者：
Lin, Jennifer;Lee, I-Min;Zhang, Shumin M.
背景：叶酸、维生素B-6和维生素B-12等B族维生素是对DNA完整性和稳定性非常重要的辅酶。目的：我们前瞻性地评估了血浆中叶酸、吡哆醛5‘-磷酸(PLP；维生素13-6的主要活性形式)和维生素B-12的浓度与乳腺癌风险的关系。设计：我们纳入了截至2004年3月31日确诊的848例浸润性乳腺癌病例，以及来自28345名女性的848名单独匹配的对照组受试者，这些受试者在1993年提供血样且在基线时没有癌症和心血管疾病病史。对配对因素和其他危险因素进行Logistic回归控制，估计乳腺癌的相对危险度(RRs)和95%的CI。结果：叶酸、PLP和维生素B-12的血浆浓度与乳腺癌的总体风险无关。最高五分位数组与最低五分位数组的多变量RRS分别为1.42(95%CI：1.00，2.02)、0.91(95%CI：0.63，1.30)、1.29(95%CI：0.92、1.82)(P趋势=0.18)。然而，较高的血浆叶酸浓度与发生绝经前乳腺癌的风险(趋势=0.04)和发生雌激素受体(ER)阳性或孕激素受体(PR)阳性的乳腺肿瘤的风险(趋势=0.04)呈中度相关(P
Background: B vitamins such as folate, vitamin B-6, and vitamin B-12 are coenzymes that are important for DNA integrity and stability. Deficiency in these B vitamins may promote tumor carcinogenesis.Objective: We prospectively evaluated plasma concentrations of folate, pyridoxal 5'-phosphate (PLP; the principal active form of vitamin 13-6), and vitamin B-12 in relation to breast cancer risk.Design: We included 848 incident cases of invasive breast cancer identified as of 31 March 2004, and 848 individually matched control subjects from 28 345 women in the Women's Health Study aged >= 45 y who provided blood samples and had no history of cancer and cardiovascular disease at baseline in 1993. Logistic regression controlling for matching factors and other risk factors for breast cancer was used to estimate relative risks (RRs) and 95% CIs. All statistical tests were 2 sided.Results: Plasma concentrations of folate, PLP, and vitamin B-12 were not associated with overall risk of breast cancer. Women in the highest quintile group relative to those in the lowest quintile had multivariate RRs of 1.42 (95% Cl: 1.00, 2.02) for plasma folate (P for trend = 0.21), 0.91 (95% CI: 0.63, 1.30) for plasma PLP (P for trend = 0.48), and 1.29 (95% CI 0.92,1.82) for plasma vitamin B-12 (P for trend = 0.18). However, higher plasma folate concentrations were moderately associated with an increased risk of developing premenopausal breast cancer (P for trend = 0.04) and for developing estrogen receptor (ER)-positive or progesterone receptor (PR)-positive breast tumors (P for trend