Essential fatty acids as possible enhancers of the beneficial actions of probiotics
Essential fatty acids as possible enhancers of the beneficial actions of probiotics
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DOI：
10.1016/s0899-9007(02)00840-7
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发表时间：
2002-09-01
期刊：
影响因子：
4.4
通讯作者：
Das, UN
中科院分区：
文献类型：
--
作者：
Das, UN
目的：我调查是否有一个共同的联系之间的必需脂肪酸和益生菌，有类似的行动和利益atopy.METHODS：我做了一个重要的审查有关的文献行动的必需脂肪酸和益生菌对免疫反应和它们之间的相互作用，特别是参考atopy.RESULTS：殖民化的人胃肠道发生在第一个月和几年的生活。益生菌是健康肠道微生物群的有益细菌的培养物，其减少饮食抗原负荷，从而防止特应性。据报道，在出生后至少4个月纯母乳喂养的儿童中，儿童哮喘和其他特应性疾病的风险显著降低。这种有益作用可归因于母乳的免疫调节、营养或其他成分母乳富含具有免疫调节作用的长链多不饱和脂肪酸（LCPUFA）。益生菌和LCPUFA调节T辅助细胞1和2的反应，表现出抗过敏作用，并减轻与过敏性炎症相关的变化。LCPUFAs促进益生菌粘附到粘膜表面，这增强了益生菌的健康促进作用。结论：鉴于其行动的相似性，因为LCPUFAs促进益生菌的行动，我相信，LCPUFAs和益生菌的组合提供显着的保护对特应性。母乳喂养和益生菌很可能是人类生命早期自然发生的两个适当事件，对健康有重大益处。(C)Elsevier Science Inc. 2002.
OBJECTIVES: I investigated whether there is a common link between essential fatty acids and probiotics, which have similar actions and benefits in atopy.METHODS: I made a critical review of the literature pertaining to the actions of essential fatty acids and probiotics on immune response and the interaction between them with particular reference to atopy.RESULTS: Colonization of the human gastrointestinal tract occurs in the first months and years of life. Probiotics are cultures of beneficial bacteria of healthy gut microflora, which reduce dietary antigen load and thus protect against atopy. A significant reduction in the risk of childhood asthma and other atopic conditions was reported in children who were exclusively breast-fed for at least 4 mo after birth. This beneficial action can be attributed to the immunomodulatory, nutritional, or other components of human milk Human breast milk is rich in long-chain polyunsaturated fatty acids (LCPUFAs), which have immunomodulatory actions. Probiotics and LCPUFAs modulate T-helper 1 and 2 responses, show antibioticlike actions, and alleviate changes related to allergic inflammation. LCPUFAs promote the adhesion of probiotics to mucosal surfaces, which augments the health-promoting effects of probiotics.CONCLUSIONS: In view of the similarity in their actions and because LCPUFAs promote the actions of probiotics, I believe that a combination of LCPUFAs and probiotics offer significant protection against atopy. It is likely that breast-feeding and probiotics are two naturally occurring, appropriate events in early human life that have significant health benefits. (C) Elsevier Science Inc. 2002.