NATURAL-HISTORY OF ANGINA-PECTORIS IN FRAMINGHAM STUDY - PROGNOSIS AND SURVIVAL
NATURAL-HISTORY OF ANGINA-PECTORIS IN FRAMINGHAM STUDY - PROGNOSIS AND SURVIVAL
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DOI：
10.1016/0002-9149(72)90624-8
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发表时间：
1972-01-01
影响因子：
2.8
通讯作者：
FEINLEIB, M
中科院分区：
文献类型：
--
作者：
KANNEL, WB;FEINLEIB, M
对5,127人的一般人群样本中的303例心绞痛病例的演变进行了查明，结果表明心绞痛患者的命运并不幸福。男性的生存和进展为更严重的冠状动脉表现的预后令人沮丧。四分之一的心绞痛男性预计会在 5 年内发生冠心病发作。对于女性来说，这种风险只有一半。 55 岁以上的人中约有 30% 将在 8 年内死亡，其中 44% 的冠心病死亡是突然的。死亡率接近心肌梗死院后阶段的死亡率。令人惊讶的是，患有单纯性心绞痛的男性的生存率并不比梗死后心绞痛的生存率好。女性（65％）比男性（37％）更可能出现心绞痛作为冠心病的主诉。在男性中，45% 的心绞痛是由心肌梗塞引起的，而女性中这一比例为 15%。一半患有初始心肌梗塞的人随后出现心绞痛，其中 31% 是第一次出现心绞痛。在患有心绞痛且持续梗塞的患者中，只有 15% 的男性心绞痛消失，而女性则没有，这一比率低于 30% 的自发消失率。只有 23% 的梗塞发生前会出现心绞痛。几乎四分之一的心肌梗塞是无症状的或未被识别的。这种梗塞在既往有心绞痛的人中很少见。
The evolution of 303 cases of angina in a general population sample of 5,127 persons was ascertained and revealed that the lot of the angina victim is not a happy one. Prognosis as to survival and progression to more serious coronary manifestations was discouraging in men. One in 4 men with angina can expect to have a coronary attack within 5 years. The risk is half this for women. About 30 percent of those over 55 will die within 8 years, and 44 percent of the coronary deaths will be sudden. Mortality was close to that which follows the posthospital phase of myocardial infarction. Surprisingly, survival in men with uncomplicated angina was no better than that for angina which follows an infarction.Angina was more likely to be the presenting complaint of coronary disease in women (65 percent) than in men (37 percent). In men 45 percent of angina arose out of myocardial infarction compared to 15 percent in women. Half of those sustaining initial myocardial infarctions had angina following it, 31 percent experiencing it for the first time. In those with angina who sustained an infarction, the angina disappeared in only 15 percent of men and no women, a rate lower than the 30 percent spontaneous rate of disappearance. Only 23 percent of infarctions were preceded by angina. Almost 1 in 4 myocardial infarctions were silent or went unrecognized. Such infarctions were rare in persons with prior angina.