The Protective Effect of Familial Longevity Persists After Age 100: Findings From the Danish National Registers.
The Protective Effect of Familial Longevity Persists After Age 100: Findings From the Danish National Registers.
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家族长寿的保护作用在 100 岁之后依然存在：来自丹麦国家登记册的调查结果。
DOI：
10.1093/gerona/glad164
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Christensen,Kaare
中科院分区：
文献类型：
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作者：
Galvin,Angéline;Pedersen,JacobKrabbe;Wojczynski,MaryK;Ukraintseva,Svetlana;Arbeev,Konstantin;Feitosa,Mary;Province,MichaelA;Christensen,Kaare
背景最近的一项研究表明，家族长寿对百岁老人的保护作用可以忽略不计。然而，作者通过比较父母一方活到80岁以上的百岁老人与同性父母没有活到80岁的百岁老人，评估了百岁老人对家庭寿命的依赖性。在这里，我们测试是否保护作用的家族寿命持续100岁后，使用更严格的定义长寿family. MethodsLong-living siblishments确定通过3个全国性的，连续的研究在丹麦，包括家庭，至少有2个兄弟姐妹年龄在90岁以上或家庭长寿选择评分（FLoSS）以上7。参加这些研究并达到100岁的长寿兄弟姐妹也被纳入其中。对于每个兄弟姐妹，在丹麦人口中的百岁老人中随机选择5个性别和出生年份匹配的对照。从100岁开始的生存时间分别用Kaplan-Meier曲线描述兄弟姐妹和对照组。生存分析采用分层考克斯比例风险models.ResultsA共340人从长寿的同胞谁存活到100岁和1700控制。在长寿的兄弟姐妹和对照组中，有1650人（81%）是女性。结果表明，长寿的兄弟姐妹提出了更好的总体生存100岁后，比零星的长肝（风险比[HR]= 0.80，95%置信区间[CI]= 0.71-0.91），甚至更低的估计（HR = 0.65，95% CI = 0.50-0.85），如果家族长寿的定义由FLoSS.ConclusionsThe本研究，几乎没有损失的后续行动，表现出持久的保护作用，家族长寿100岁后。
BackgroundA recent study suggested that the protective effect of familial longevity becomes negligible for centenarians. However, the authors assessed the dependence on familial longevity in centenarians by comparing centenarians with 1 parent surviving to age 80+ to centenarians whose same-sexed parent did not survive to age 80. Here we test whether the protective effect of familial longevity persists after age 100 using more restrictive definitions of long-lived families.MethodsLong-lived sibships were identified through 3 nationwide, consecutive studies in Denmark, including families with either at least 2 siblings aged 90+ or a Family Longevity Selection Score (FLoSS) above 7. Long-lived siblings enrolled in these studies and who reached age 100 were included. For each sibling, 5 controls matched on sex and year of birth were randomly selected among centenarians in the Danish population. Survival time from age 100 was described with Kaplan–Meier curves for siblings and controls separately. Survival analyses were performed using stratified Cox proportional hazards models.ResultsA total of 340 individuals from long-lived sibships who survived to age 100 and 1 700 controls were included. Among the long-lived siblings and controls, 1 650 (81%) were women. The results showed that long-lived siblings presented better overall survival after age 100 than sporadic long-livers (hazard ratio [HR] = 0.80, 95% confidence interval [CI] = 0.71–0.91), with even lower estimate (HR = 0.65, 95% CI = 0.50–0.85) if familial longevity was defined by FLoSS.ConclusionsThe present study, with virtually no loss to follow-up, demonstrated a persistence of protective effect of familial longevity after age 100.