Cholestane steroid glycosides from the rhizomes of Dioscorea villosa (wild yam)
Cholestane steroid glycosides from the rhizomes of Dioscorea villosa (wild yam)
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DOI：
10.1016/j.carres.2012.12.022
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发表时间：
2013-04-05
影响因子：
3.1
通讯作者：
Khan, Ikhlas A.
中科院分区：
文献类型：
--
作者：
Ali, Zulfiqar;Smillie, Troy J.;Khan, Ikhlas A.
对薯蓣根茎的甲醇提取物进行植物化学研究，分离出两种新的双链胆甾烷类固醇糖苷，薯蓣苷 A 和 B（1 和 2）。此外，提取物还产生了 12 种先前已知的 furostan 和 spirostan 类固醇糖苷 (3-14)，以及薯蓣皂苷元 (15)。化合物3-7、9、14和15为首次从D. villosa中分离得到。使用光谱和化学方法（包括一维和二维核磁共振）确定了分离化合物的结构。大多数这些化合物的抗菌作用针对五种真菌和五种细菌菌株进行了测试。 (C) 2013 Elsevier Ltd. 保留所有权利。
Phytochemical investigation of the MeOH extract of Dioscorea villosa rhizomes resulted in the isolation of two new bidesmosidic cholestane steroid glycosides, dioscoreavillosides A and B (1 and 2). In addition, the extract yielded 12 previously known furostan and spirostan steroid glycosides (3-14), along with diosgenin (15). Compounds 3-7, 9, 14, and 15 were isolated for the first time from D. villosa. The structures of the isolated compounds were determined using spectroscopic and chemical methods including 1D and 2D NMR. The antimicrobial action of most of these compounds was tested against five fungal and five bacterial strains. (C) 2013 Elsevier Ltd. All rights reserved.