PHASIC BLOOD-FLOW VELOCITY PATTERN IN EPIMYOCARDIAL MICROVESSELS IN THE BEATING CANINE LEFT-VENTRICLE
PHASIC BLOOD-FLOW VELOCITY PATTERN IN EPIMYOCARDIAL MICROVESSELS IN THE BEATING CANINE LEFT-VENTRICLE
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DOI：
10.1161/01.res.59.6.704
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发表时间：
1986-12-01
影响因子：
20.1
通讯作者：
TAKISHIMA, T
中科院分区：
文献类型：
--
作者：
ASHIKAWA, K;KANATSUKA, H;TAKISHIMA, T
我们定量了搏动左心室的时相心肌微循环冠状动脉血流速度模式。使用新开发的浮动物镜和高速电影摄影技术，在整个心动周期内测定了小动脉、毛细血管和小静脉中的红细胞速度以及跳动左心室心肌外膜浅层的微血管直径。开胸麻醉狗。左心房起搏维持心率140次/分。红细胞峰值流速出现在小动脉和毛细血管的收缩中期，小静脉的收缩晚期。在射血前期，在这些微血管中观察到红细胞速度的突然下降，在许多情况下，短暂的停止或反向流动。小微静脉的内径在收缩晚期增大，而小微动脉的内径在心动周期中基本不变。此外，在这些肌外膜微血管中，射血相的速度曲线下面积占总面积的百分比较高;小动脉占51%，毛细血管占43%，小静脉占40%。这些结果表明，在大的心外膜动脉和间隔动脉的时相血流模式是显着不同的，在肱肌下微血管。在地拉卓（50 μ g/kg，静脉注射）后的血管舒张期间，腺苷增强剂，在整个心动周期中，心肌外膜微血管中红细胞速度增加，速度曲线下的总面积显著增加，伴随着小动脉的显著扩张。目前的数据将提供有用的信息，在预测模拟跨壁的相位血流模式的差异。
We quantitated phasic epimyocardial microcirculatory coronary blood flow velocity patterns in the beating left ventricle. Using a newly developed floating objective and high-speed cinematography, red cell velocities in small arterioles, capillaries, and small venules and microvascular diameters in the superficial layer of the epimyocardium of beating left ventricle were determined throughout the entire cardiac cycle in open-chest anesthetized dogs. Heart rate was maintianed at 140 beats/min by means of left atrial pacing. Peak red cell velocity was observed in midsystole in small arterioles and capillaries, and in late systole in small venules. Abrupt decline in red cell velocity and, in many cases, a momentary cessation or reverse of flow, was observed in these microvessels during the pre-ejection period. The internal diameter of small venule was increased in late systole, while that of small arteriole remained almost constant during the cardiac cycle. Furthermore, in these epimyocardial microvessels, a higher percentage of the total area under the velocity curve occurred during the ejection phase; 51% in small arterioles, 43% in capillaries, and 40% in small venules. These findings indicate that the phasic blood flow pattern is markely different in the subepimyocardial microvessels from that in the large epicardial artery and the septal artery. During vasodilation following dilazep (50 .mu.g/kg, i.v.), an adenosine potentiator, red cell velocity increased throughout the entire cardiac cycle in epimyocardial microvessels with significant increases in the total area under the velocity curves accompanied by significant dilation of the arterioles. The present data will provide information useful in predicting for simulating transmural differences in the phasic blood flow pattern.