Does measurement site for visceral and abdominal subcutaneous adipose tissue alter associations with the metabolic syndrome?
Does measurement site for visceral and abdominal subcutaneous adipose tissue alter associations with the metabolic syndrome?
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DOI：
10.2337/diacare.29.03.06.dc05-1500
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发表时间：
2006-03-01
期刊：
影响因子：
16.2
通讯作者：
Ross, R
中科院分区：
文献类型：
--
作者：
Kuk, JL;Church, TS;Ross, R
目的：确定内脏脂肪组织（VAT）、腹部皮下脂肪组织（ASAT）与代谢综合征之间的关联是否会因VAT和ASAT的测量部位以及用于识别代谢综合征的定义而改变。研究设计和方法：使用类似于85名男性T10-T11至L5-S1的37张连续计算机断层扫描（CT）图像，得出VAT和ASAT的总体积。在8个椎间位置（如L4-L5、L3-L4等）获得的CT图像用于确定部分体积（单幅图像）与代谢综合征之间的关系。代谢综合征的定义采用国家胆固醇教育计划（NCEP）和国际糖尿病联合会（IDF）标准。逻辑回归，vas用于计算赔率。脂肪组织中每SD增加的比率（OR）。结果-对于总体积和所有部分体积，VAT比ASAT与代谢综合征的相关性更强，与代谢综合征标准无关。NCEP代谢综合征的总增值率（OR = 7.26）、T12-L1部分容积（OR = 7.46）和L1-L2部分容积（OR = 8.77）高于L4-L5水平（OR = 3.94）。代谢综合征的OR（与2.6相似）在ASAT测量中没有实质性差异。使用IDF代谢综合征标准观察到类似的关联模式。结论：VAT的测量地点，而不是ASAT的测量地点，对与两种代谢综合征定义的关联程度有实质性影响。然而，由于无论测量地点如何，VAT仍与代谢综合征显著相关，因此临床解释不会因测量方案或代谢综合征定义而改变。
OBJECTIVE - To determine whether the associations between visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (ASAT), and the metabolic syndrome are altered depending on measurement site for VAT and ASAT and the definition used to identify the metabolic syndrome.RESEARCH DESIGN AND METHODS - Total VAT and ASAT volume was derived using similar to 37 contiguous Computed tomography (CT) images from T10-T11 to L5-S1 in 85 men. CT images obtained at eight intervertebral locations (e.g., L4-L5, L3-L4, etc.) were used to determine the associations between partial volumes (single images) and metabolic syndrome. Metabolic syndrome was defined using the National Cholesterol Education Program (NCEP) and International Diabetes Federation (IDF) criteria. Logistic regression,vas used to calculate the odds. ratio (OR) per SD increase in adipose tissue.RESULTS - For total and all partial volumes, VAT was more strongly associated with metabolic syndrome than ASAT independent of metabolic syndrome criteria. The OR (per SD) for NCEP metabolic syndrome was higher for total VAT Volume (OR = 7.26) and for the partial volumes at T12-L1 (7.46) and L1-L2 (8.77) than those at the L4-L5 level (3.94). The OR for metabolic syndrome (similar to 2.6) was not substantially different among the ASAT measures. A similar pattern of association was observed using the IDF metabolic syndrome criteria.CONCLUSIONS- The measurement Site for VAT, but not for ASAT, has a substantial influence on the magnitude of the association with both metabolic syndrome definitions. However, because VAT remained significantly associated With metabolic syndrome regardless of measurement site, the clinical interpretation was unaltered by measurement protocol or metabolic syndrome definition.