Biomarkers: FAK autophosphorylation independently predicts recurrence of gastric cancer.
Biomarkers: FAK autophosphorylation independently predicts recurrence of gastric cancer.
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DOI：
10.1038/nrgastro.2010.162
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发表时间：
2010-11-01
期刊：
影响因子：
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通讯作者：
Nanda, Shreeya
中科院分区：
文献类型：
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作者：
Nanda, Shreeya
分别将样本与同一患者非癌组织中的水平进行比较。Ptyr397FAK过表达的患者与ptyr397FAK染色不高的患者相比，5年无复发生存率降低。相比之下，FAK过表达和不过表达的患者的5年无复发生存率相似。Ptyr397的过度表达也强烈预测了胃癌手术切除后的复发。沈阳总结道：“FAK在细胞迁移和增殖中起着至关重要的作用，这种酶在各种肿瘤中的水平都会升高，这表明FAK可能参与了恶性肿瘤的发展。”
samples, respectively, compared with their levels in noncancerous tissue from the same patient. Patients with ptyr397 FaK overexpression had decreased 5-year recurrence-free survival compared with those who did not have high levels of ptyr397 FaK staining. By contrast, 5-year recurrence-free survival was similar for individuals with and without FaK overexpression. ptyr397 overexpression was also strongly predictive of gastric cancer recurrence after surgical resection.“FaK has a crucial role in cell migration and proliferation, and levels of this enzyme are elevated in a variety of tumors, suggesting that FaK might be involved in the development of malignancies,” concludes shen.