Melatonin alters behavior and cAMP levels in nucleus accumbens induced by cocaine treatment.
Melatonin alters behavior and cAMP levels in nucleus accumbens induced by cocaine treatment.
复制标题
褪黑激素改变可卡因治疗诱导的伏核行为和 cAMP 水平。
DOI：
10.1016/s0006-8993(02)03565-5
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发表时间：
2002
期刊：
影响因子：
2.9
通讯作者：
Giorgetti,Marco
中科院分区：
文献类型：
--
作者：
Zhdanova,IrinaV;Giorgetti,Marco
This study describes the effects of melatonin on cocaine-induced anxiety-like behavior and nucleus accumbens (NAc) cAMP levels in rats. Animals drinking a solution of melatonin (200 ng/ml) at night, either during repeated cocaine administration (15 mg/kg i.p., twice a day for 9 days) or during its withdrawal, showed less anxiety-like behavior in a defensive withdrawal paradigm 48 h after the last injection of cocaine. Melatonin did not alter behavior in control rats treated with saline. Animals exposed for 1 week to unrestricted free-choice oral melatonin self-administration (200 ng/ml) did not show preference for the drinking solution containing melatonin. Pretreatment with melatonin (200 ng/kg i.p. or 200 ng/ml orally) significantly attenuated the augmentation of cAMP levels in NAc following acute cocaine administration (15 mg/kg i.p.). Taken together, these results suggest that a low-dose night-time melatonin treatment results in anxiolytic-like effects in rats withdrawn from repeated cocaine administration, can antagonize cocaine-induced activation of NAc cAMP levels and has low dependence liability.
