P2X4 receptors, immunity, and sepsis
P2X4 receptors, immunity, and sepsis
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DOI：
10.1016/j.coph.2019.02.011
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发表时间：
2019-08-01
影响因子：
4
通讯作者：
Hasko, Gyorgy
中科院分区：
文献类型：
--
作者：
Antonioli, Luca;Blandizzi, Corrado;Hasko, Gyorgy
脓毒症是由宿主对感染性损伤的反应失调引起的危及生命的全身器官功能障碍。目前，脓毒症的治疗仅限于使用抗生素、液体和心血管/呼吸支持。尽管采取了这些干预措施，脓毒性死亡率仍然很高，幸存者的生活质量下降。因此，寻找新的药物作用靶点是现代药理学的一项紧迫任务。根据最近的研究，似乎P2嘌呤能受体，它可以调节宿主对感染的反应，已被确定为治疗脓毒症的潜在靶点。在P2受体中，P2 X（4）受体最近引起了研究界的注意，因为它在保护免受感染、炎症和器官损伤中的作用。本文综述了P2 X（4）受体在调节宿主对脓毒症的反应中所起的作用，以及靶向该受体治疗脓毒症的前景。
Sepsis is life-threatening systemic organ dysfunction caused by a deregulated host response to an infectious insult. Currently, the treatment of sepsis is limited to the use of antibiotics, fluids, and cardiovascular/respiratory support. Despite these interventions, septic mortality remains high, with reduced life quality in survivors. For this reason, the identification of novel drug targets is a pressing task of modern pharmacology. According to a recent research, it appears that P2 purinergic receptors, which can regulate the host's response to infections, have been identified as potential targets for the treatment of sepsis. Among P2 receptors, the P2X(4) receptor has recently captured the attention of the research community owing to its role in protecting against infections, inflammation, and organ injury. The present review provides an outline of the role played by P2X(4) receptors in the modulation of the host's response to sepsis and the promise that targeting this receptor holds in the treatment of sepsis.