Isolation of chlorine-containing antibiotic from the freshwater cyanobacterium Scytonema hofmanni.
Isolation of chlorine-containing antibiotic from the freshwater cyanobacterium Scytonema hofmanni.
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DOI：
10.1126/science.6800032
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发表时间：
1982-01
期刊：
影响因子：
56.9
通讯作者：
C. Mason;K. Edwards;R. E. Carlson;J. Pignatello;F. K. Gleason;J. Wood
中科院分区：
文献类型：
--
作者：
C. Mason;K. Edwards;R. E. Carlson;J. Pignatello;F. K. Gleason;J. Wood
霍夫曼蓝丝藻是一种丝状的淡水蓝藻（蓝绿色藻），它产生的次生代谢产物能抑制其他蓝藻和绿色藻类的生长。一种快速，定性测定这种抑制已经开发与聚球藻作为测试生物。该测定程序导致从Scytonema中分离和表征抗生素（命名为蓝细菌素）。该抗生素的分子量为430，经验式为C23 H23 O 6Cl，含有γ-内酯和氯代芳香核。它抑制各种藻类的生长，但对非光合细菌或原生动物的影响有限，因此可能具有作为特定杀藻剂的潜在用途。
Scytonema hofmanni, a filamentous freshwater cyanobacterium (blue-green alga), produces secondary metabolites which inhibit the growth of other cyanobacteria and green algae. A rapid, qualitative assay for this inhibition has been developed with Synechococcus as the test organism. This assay procedure has led to the isolation and characterization of an antibiotic (named cyanobacterin) from Scytonema. The antibiotic has a molecular weight of 430 and an empirical formula of C23H23O6Cl and contains a gamma-lactone and a chlorinated aromatic nucleus. It inhibits the growth of various algae but has limited effect on nonphotosynthetic bacteria or protozoans and thus may have potential use as a specific algicide.