ETHANOL INCREASES SINGLE UNIT-ACTIVITY IN THE INFERIOR OLIVARY NUCLEUS
ETHANOL INCREASES SINGLE UNIT-ACTIVITY IN THE INFERIOR OLIVARY NUCLEUS
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DOI：
10.1016/0006-8993(86)91071-1
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发表时间：
1986-10-22
期刊：
影响因子：
2.9
通讯作者：
SIGGINS, GR
中科院分区：
文献类型：
--
作者：
ROGERS, J;MADAMBA, SG;SIGGINS, GR
急性腹腔注射2g/kg乙醇后，大鼠下橄榄核神经元放电频率显著增加。这种效果在3种不同的麻醉和固定方法中是一致的：局部利多卡因加腹膜内D-管箭毒、腹膜内水合氯醛和氟烷蒸汽。相反，在乌拉坦麻醉下，急性乙醇产生显著的橄榄放电抑制。由于这种效应与其他麻醉条件下发现的效应相反（包括仅局部Xylocaine），氨基甲酸乙酯麻醉可能会影响乙醇电生理学研究的概括。下橄榄核的神经元兴奋小脑浦肯野细胞通过一个强大的传入电路，因此，我们的数据表明，乙醇诱导的增加小脑浦肯野细胞复合体（攀爬纤维爆发）尖峰，在我们以前的研究中获得的，是继发于橄榄激活。
Single unit recording of rat inferior olivary nucleus neurons reveals significantly elevated discharge rates after acute intraperitoneal injection of 2 g/kg ethanol. This effect is consistent across 3 different methods of anesthesia and immobilization: local Xylocaine plus intraperitoneal D-tubocurare, intraperitoneal chloral hydrate and halothane vapor. In contrast, under urethane anesthesia acute ethanol produces significant depression of olivary discharge. Since this effect is opposite to that found under the other anesthetic conditions (including topical Xylocaine only), urethane anesthesia may compromise generalizations of electrophysiologic studies of ethanol. Neurons of the inferior olivary nucleus excite cerebellar Purkinje cells through a powerful afferent circuit; our data therefore suggest that ethanol-induced increase in cerebellar Purkinje cell complex (climbing fiber burst) spikes, obtained in our previous studies, are secondary to olivary activation.