Synchronous secretion of luteinizing hormone and prolactin in the human luteal phase: neuroendocrine mechanisms.
Synchronous secretion of luteinizing hormone and prolactin in the human luteal phase: neuroendocrine mechanisms.
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人黄体期黄体生成素和催乳素的同步分泌：神经内分泌机制。
DOI：
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发表时间：
1984
影响因子：
5.8
通讯作者：
S. Judd
中科院分区：
文献类型：
--
作者：
W. Braund;D. Roeger;S. Judd
对正常黄体期妇女的研究表明，血清LH和PRL的升高通常是同步的。本研究旨在研究这种现象背后可能的神经内分泌机制。6名正常妇女在2个周期的黄体中期进行了研究。在第一个周期中，他们有3次在6小时内每隔15分钟采集血样，在此期间，他们接受了生理盐水或纳洛酮（1 mg/h）或胃复安（10 mg，iv）的推注。在第二个周期中，他们以2小时的间隔接受1，10和50微克的静脉注射剂量的GnRH。在生理盐水输注过程中，16次血清LH脉冲中有11次（69%）伴有血清PRL升高，其中5例LH脉冲与PRL脉冲同步（P = 0.0015）。纳洛酮使LH脉冲数从16个增加到20个，PRL脉冲数从12个增加到16个，均与LH脉冲同步。甲氧氯普胺给药导致PRL大幅增加，并进一步丧失PRL脉动性;然而，LH脉动性未受影响。即使在最小剂量的GnRH（1微克）后，血清PRL [基础水平，11.8 +/- 2.1（+/- SE）微克/升;峰值水平，16.5 +/- 3.3微克/升]以及LH和FSH也增加。与促性腺激素反应不同，血清PRL的增加在10微克剂量的GnRH后达到最大（峰值水平，23.2 +/- 6微克/升），在50微克剂量后没有进一步增加（峰值水平，18.5 +/- 2.4微克/升）。这些研究表明，在黄体期存在PRL对GnRH的反应，并表明此时观察到的LH和PRL分泌的同步性是促性腺激素和催乳激素对内源性GnRH的生理反应的结果。
Studies of normal luteal phase women have shown that increases in serum LH and PRL are commonly synchronous. This study was designed to investigate the possible neuroendocrine mechanism(s) underlying this phenomenon. Six normal women were studied during the midluteal phase of 2 cycles. In the first cycle, they had blood samples collected at 15-min intervals for 6 h on 3 occasions during which time they received an infusion of normal saline or naloxone (1 mg/h) or a bolus of metoclopramide (10 mg, iv). In a second cycle, they received GnRH in increasing iv doses of 1, 10, and 50 micrograms at 2-h intervals. During the saline infusion, 11 of the 16 serum LH pulses (69%) were accompanied by an increase in serum PRL, and in 5 of the subjects, the first pulse of LH was synchronous with that of PRL (P = 0.0015). Naloxone increased the number of LH pulses from 16 to 20 and the number of PRL pulses from 12 to 16, all of which were synchronous with LH pulses. Administration of metoclopramide caused a substantial increase in PRL and a loss of further PRL pulsatility; however, LH pulsatility remained unaffected. Even after the smallest dose of GnRH (1 microgram), there was an increase in serum PRL [basal level, 11.8 +/- 2.1 (+/- SE) micrograms/liter; peak level, 16.5 +/- 3.3 micrograms/liter] as well as LH and FSH. The increase in serum PRL was, unlike the gonadotropin response, maximal after the 10-microgram dose of GnRH (peak level, 23.2 +/- 6 micrograms/liter) and did not increase further after the 50-micrograms dose (peak level, 18.5 +/- 2.4 micrograms/liter). These studies demonstrate that there is a PRL response to GnRH in the luteal phase and suggest that the observed synchrony in LH and PRL secretion at this time results from a physiological response of both the gonadotrope and the lactotrope to endogenous GnRH.
黄体生成素释放因子激动剂诱导催乳素和黄体生成素同时脉冲式释放。
DOI：
10.1210/jcem-52-5-934
发表时间：
1981
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Casper,RF;Yen,SS
通讯作者：
Yen,SS
有证据表明，促甲状腺素释放激素和下丘脑催乳素释放因子可能在哺乳大鼠催乳素的释放中发挥作用。
影响因子：
4.8
作者：
Grosvenor,CE;Mena,F
通讯作者：
Mena,F
黄体酮和 20α-羟基黄体酮刺激离体的下丘脑内侧基底层体外释放 GnRH。
影响因子：
6.1
作者：
Rasmussen,DD;Yen,SS
通讯作者：
Yen,SS