Dopamine modulation of emotional processing in cortical and subcortical neural circuits: Evidence for a final common pathway in schizophrenia?
Dopamine modulation of emotional processing in cortical and subcortical neural circuits: Evidence for a final common pathway in schizophrenia?
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DOI：
10.1093/schbul/sbm048
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发表时间：
2007-07-01
影响因子：
6.6
通讯作者：
Laviolette, Steven R.
中科院分区：
文献类型：
--
作者：
Laviolette, Steven R.
情绪感知、学习和记忆的神经调节对于正常的行为和认知功能是必不可少的。精神分裂症患者表现出的许多症状可能是由于准确处理情绪上突出的感觉信息的能力的根本障碍。神经递质多巴胺(DA)及其调节涉及情绪学习、感知和记忆形成的神经区的能力已经受到相当多的研究关注，作为解释精神分裂症综合征中存在的异常情绪调节和精神障碍的潜在的最终共同途径。来自人类神经成像研究和基于动物的神经发育、行为和电生理研究的证据表明，中皮质边缘DA回路是编码和表达情绪显著学习和记忆形成的关键系统。虽然许多理论研究了前额叶皮质区域和皮质下DA底物之间的皮质-皮质下相互作用，但关于DA如何控制情绪知觉和学习，以及与DA异常相关的干扰如何可能是精神分裂症患者情绪加工障碍的基础，仍有许多问题。除了中脑边缘DA系统，越来越多的证据表明杏仁核-前额叶皮质回路是情绪显著信息的重要处理器，以及该回路内的神经发育扰动如何导致沿着皮质-皮质下情绪处理回路的情绪处理和学习的DAER能调制的失调。
The neural regulation of emotional perception, learning, and memory is essential for normal behavioral and cognitive functioning. Many of the symptoms displayed by individuals with schizophrenia may arise from fundamental disturbances in the ability to accurately process emotionally salient sensory information. The neurotransmitter dopamine (DA) and its ability to modulate neural regions involved in emotional learning, perception, and memory formation has received considerable research attention as a potential final common pathway to account for the aberrant emotional regulation and psychosis present in the schizophrenic syndrome. Evidence from both human neuroimaging studies and animal-based research using neurodevelopmental, behavioral, and electrophysiological techniques have implicated the mesocorticolimbic DA circuit as a crucial system for the encoding and expression of emotionally salient learning and memory formation. While many theories have examined the cortical-subcortical interactions between prefrontal cortical regions and subcortical DA substrates, many questions remain as to how DA may control emotional perception and learning and how disturbances linked to DA abnormalities may underlie the disturbed emotional processing in schizophrenia. Beyond the mesolimbic DA system, increasing evidence points to the amygdala-prefrontal cortical circuit as an important processor of emotionally salient information and how neurodevelopmental perturbances within this circuitry may lead to dysregulation of DAergic modulation of emotional processing and learning along this cortical-subcortical emotional processing circuit.