Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation
Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation
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DOI：
10.1242/dev.02724
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发表时间：
2007-01-15
期刊：
影响因子：
4.6
通讯作者：
Robb, Lorraine
中科院分区：
文献类型：
--
作者：
Tam, Patrick P. L.;Khoo, Poh-Lynn;Robb, Lorraine
在小鼠原肠发育过程中，前肠背侧的内胚层细胞先于腹侧前肠被招募，并通过不同的途径移动到胚胎的前部。前肠最前部和中后肠的前体被分配到条纹中期胚胎的内胚层，而其余前肠的前体在原肠形成的后期被招募。Mixl1功能的丧失会导致最终内胚层的募集减少，并导致内胚层中的细胞在原肠形成过程中保持静止。在Mixl1缺失突变体中，尽管中胚层扩张，内胚层细胞却天生不能移动，这表明内胚层和中胚层的运动是相互独立地驱动的。
During mouse gastrulation, endoderm cells of the dorsal foregut are recruited ahead of the ventral foregut and move to the anterior region of the embryo via different routes. Precursors of the anterior-most part of the foregut and those of the mid- and hind-gut are allocated to the endoderm of the mid-streak-stage embryo, whereas the precursors of the rest of the foregut are recruited at later stages of gastrulation. Loss of Mixl1 function results in reduced recruitment of the definitive endoderm, and causes cells in the endoderm to remain stationary during gastrulation. The observation that the endoderm cells are inherently unable to move despite the expansion of the mesoderm in the Mixl1-null mutant suggests that the movement of the endoderm and the mesoderm is driven independently of one another.