Magnetic bead manipulation in a sub-microliter fluid volume applicable for biosensing
Magnetic bead manipulation in a sub-microliter fluid volume applicable for biosensing
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DOI：
10.1007/s10404-006-0112-9
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发表时间：
2007-04-01
影响因子：
2.8
通讯作者：
Prins, M. W. J.
中科院分区：
文献类型：
--
作者：
Derks, R. J. S.;Dietzel, A.;Prins, M. W. J.
本文研究了悬浮在流体中的超顺磁珠的磁致动原理。设计并制造了一个实验装置，该装置包含由四个小型化电磁体包围的亚微升流体体积。在光速测量的基础上，分析了单珠和有序链的诱导行为，并与理论模型进行了比较。这项研究可用于开发新的技术，加速运输在实验室芯片生物测定。
Magnetic actuation principles using superparamagnetic beads suspended in a fluid are studied in this paper. An experimental setup containing a sub-microliter fluid volume surrounded by four miniaturized electromagnets was designed and fabricated. On the basis of optical velocity measurements, the induced behavior of single beads and ordered chains was analyzed and compared to a theoretical model. This research can be used to develop new techniques for accelerated transportation in lab-on-a-chip bio-assays.