Negishi cross-coupling of secondary alkylzinc halides with aryl/heteroaryl halides using Pd-PEPPSI-IPent
Negishi cross-coupling of secondary alkylzinc halides with aryl/heteroaryl halides using Pd-PEPPSI-IPent
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DOI：
10.1039/c0cc04835f
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Organ, Michael G.
中科院分区：
文献类型：
--
作者：
Calimsiz, Selcuk;Organ, Michael G.
Pd-PEPPSI-IPent已被证明是仲烷基锌试剂与各种芳基/杂芳基卤化物的Negishi交叉偶联反应的优异催化剂。重要的是，使用高位阻的配体，有机金属的β-氢化物消除/迁移插入导致异构体偶联产物的产生已经显著减少。
Pd-PEPPSI-IPent has proven to be an excellent catalyst for the Negishi cross-coupling reaction of secondary alkylzinc reagents with a wide variety of aryl/heteroaryl halides. Importantly, beta-hydride elimination/migratory insertion of the organometallic leading to the production of isomeric coupling products has been significantly reduced using the highly-hindered Ipent ligand.