Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9)
Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9)
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DOI：
10.1016/s0167-4889(98)00144-x
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发表时间：
1998-12-10
影响因子：
5.1
通讯作者：
Sorg, C
中科院分区：
文献类型：
--
作者：
Kerkhoff, C;Klempt, M;Sorg, C
两个迁移抑制因子相关蛋白-8(MRP8；S100A8X)和MRP14(S100A9)是S100家族中的两个钙结合蛋白。这些蛋白在髓系分化过程中表达，在粒细胞和单核细胞中含量丰富，并以钙离子依赖的方式形成异二聚体复合体。表达MRP8和MRP14的吞噬细胞属于早期浸润性细胞，在急性炎症病变中占主导地位。此外，在患有囊性纤维化、类风湿性关节炎和慢性支气管炎等多种炎症性疾病的患者中，发现血清MRP8和MRP14水平升高，这表明这些蛋白可能具有细胞外作用。虽然已经提出了MRP8/14的一些可能的功能，但其生物学功能仍然不清楚。本文综述了MRP14介导的促进白细胞-内皮细胞相互作用的最新进展，以及MRP8/14异源二聚体作为脂肪酸结合蛋白复合体的特征。鉴于目前的知识，作者将假设MRP8和MRP14在白细胞转运中发挥重要作用，但不影响中性粒细胞效应功能。(C)1998 Elsevier Science B.V.保留所有权利。
The two migration inhibitory factor- (MIF)-related protein-8 (MRP8; S100A8X) and MRP14 (S100A9) are two calcium-binding proteins of the S100 family. These proteins are expressed during myeloid differentiation, are abundant in granulocytes and monocytes, and form a heterodimeric complex in a Ca2+-dependent manner. Phagocytes expressing MRP8 and MRP14 belong to the early infiltrating cells and dominate acute inflammatory lesions. In addition, elevated serum levels of MRP8 and MRP14 have been found in patients suffering from a number of inflammatory disorders including cystic fibrosis, rheumatoid arthritis, and chronic bronchitis, suggesting conceivable extracellular roles for these proteins. Although a number of possible functions for MRP8/14 have been proposed, the biological function still remains unclear. This review addresses recent developments regarding the MRP14-mediated promotion of leukocyte-endothelial cell-interactions and the characterization of MRP8/14 heterodimers as a fatty acid binding protein complex. In view of the current knowledge, the authors will hypothesize that MRP8 and MRP14 play an important role in leukocyte trafficking, but do not affect neutrophil effector functions. (C) 1998 Elsevier Science B.V. All rights reserved.