Impact of MR Acquisition Parameters on DTI Scalar Indexes: A Tractography Based Approach.
Impact of MR Acquisition Parameters on DTI Scalar Indexes: A Tractography Based Approach.
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DOI：
10.1371/journal.pone.0137905
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Aja-Fernández S
中科院分区：
文献类型：
--
作者：
Barrio-Arranz G;de Luis-García R;Tristán-Vega A;Martín-Fernández M;Aja-Fernández S
采集参数在扩散张量成像(DTI)中起着至关重要的作用，因为它们对分数各向异性(FA)或平均扩散率(MD)等标量测量的值有很大影响，这些测量通常是基于脑白质分析的临床研究的重点。本文分析了几个捕获参数的变化对这些标量测量的影响，并提出了一种新的双焦点。首先，由于大量的临床研究是使用这种技术进行的，因此采用了一种基于气管造影术的方法。其次，分析了多个参数同时变化的结果：梯度方向数、b值和体素分辨率。结果表明，FA受梯度数和体素分辨率变化的影响最大，而MD受b值变化的影响特别大。即使跟踪算法的选择对最终标量测量的数值有影响，当采集参数被修改时，这些测量的演变是平行的。
Acquisition parameters play a crucial role in Diffusion Tensor Imaging (DTI), as they have a major impact on the values of scalar measures such as Fractional Anisotropy (FA) or Mean Diffusivity (MD) that are usually the focus of clinical studies based on white matter analysis. This paper presents an analysis on the impact of the variation of several acquisition parameters on these scalar measures with a novel double focus. First, a tractography-based approach is employed, motivated by the significant number of clinical studies that are carried out using this technique. Second, the consequences of simultaneous changes in multiple parameters are analyzed: number of gradient directions, b-value and voxel resolution. Results indicate that the FA is most affected by changes in the number of gradients and voxel resolution, while MD is specially influenced by variations in the b-value. Even if the choice of a tractography algorithm has an effect on the numerical values of the final scalar measures, the evolution of these measures when acquisition parameters are modified is parallel.