Intra-abdominal fat area is a predictor for new onset of individual components of metabolic syndrome: MEtabolic syndRome and abdominaL ObesiTy (MERLOT study)
Intra-abdominal fat area is a predictor for new onset of individual components of metabolic syndrome: MEtabolic syndRome and abdominaL ObesiTy (MERLOT study)
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DOI：
10.2183/pjab.88.454
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发表时间：
2012-10-01
影响因子：
3.1
通讯作者：
Nakao, Kazuwa
中科院分区：
文献类型：
--
作者：
Nakao, Yoko M.;Miyawaki, Takashi;Nakao, Kazuwa
目的：探讨腹内脂肪面积（IAFA）对代谢综合征各组分（高血压、血脂异常或高血糖）新发的意义。方法：采用纵向研究方法，对某医院1994 - 2010年的体检资料进行分析。在25，255名受试者中，我们检查了1，380名日本人，他们接受了计算机断层扫描以测量IAFA，并且在基线时没有代谢综合征成分。结果：在平均3.6年的随访期内，752例受试者发生了代谢综合征的一种。在这三个组成部分中，高血压更为普遍。多元考克斯回归分析显示IAFA与代谢综合征组分的发生显著相关（HR：1.05/10 cm（2），95%CI：1.03-1.07）。这一发现与体重指数无关;即使在体重指数为1.50的非肥胖个体中也有意义。
Objective: To investigate the significance of intra-abdominal fat area (IAFA) on new onset of individual components of the metabolic syndrome: high blood pressure, dyslipidemia, or hyperglycemia. Methods: We conducted a longitudinal study using checkup data of a hospital from 1994 to 2010. Of 25,255 subjects, we examined 1,380 Japanese, who underwent computed tomography to measure IAFA and had no metabolic syndrome components at baseline. Results: During 3.6 years of the mean follow-up period, one of metabolic syndrome components occurred in 752 subjects. Of three components, high blood pressure was more prevalent. The multiple Cox regression analysis disclosed that IAFA is significantly associated with onset of metabolic syndrome components (HR: 1.05 per 10 cm(2), 95%CI: 1.03-1.07). This finding was independent of BMI; and significant even in non-obese individuals with body mass index