The lavender plumage colour in Japanese quail is associated with a complex mutation in the region of MLPH that is related to differences in growth, feed consumption and body temperature.
The lavender plumage colour in Japanese quail is associated with a complex mutation in the region of MLPH that is related to differences in growth, feed consumption and body temperature.
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DOI：
10.1186/1471-2164-13-442
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发表时间：
2012-08-31
期刊：
影响因子：
4.4
通讯作者：
Minvielle F
中科院分区：
文献类型：
--
作者：
Bed'hom B;Vaez M;Coville JL;Gourichon D;Chastel O;Follett S;Burke T;Minvielle F
鹌鹑的淡紫色表型是羽毛中真黑素和褐黑素的稀释，在野生型羽毛图案背景上产生蓝灰色。以前已经通过属间杂交证明，鹌鹑中的淡紫色突变与鸡中的相同表型同源，这是由MLPH外显子1中的单个碱基对改变引起的。在这项研究中，我们已经表明，MLPH突变也与鹌鹑羽色稀释，但突变事件是非常不同的。在该物种中，熏衣草表型与涉及三个连续重叠的染色体变化（两个倒位和一个缺失）的非致死性复杂突变相关，这对四个基因（MLPH和相邻的PRLH，RAB 17和LRRFIP 1）的基因组组织产生影响。PRLH的缺失对循环催乳素水平没有影响。与野生型羽鹌鹑相比，熏衣草型鹌鹑体重轻、体温低、耗料量和残馀采食量增加，表明这种复杂的突变正在影响代谢和恒温调节。广泛的重叠染色体重排与非病理性孟德尔性状和轻微的，无害的影响，在熏衣草日本鹌鹑，这是一个自然敲除PRLH。
The lavender phenotype in quail is a dilution of both eumelanin and phaeomelanin in feathers that produces a blue-grey colour on a wild-type feather pattern background. It has been previously demonstrated by intergeneric hybridization that the lavender mutation in quail is homologous to the same phenotype in chicken, which is caused by a single base-pair change in exon 1 of MLPH. In this study, we have shown that a mutation of MLPH is also associated with feather colour dilution in quail, but that the mutational event is extremely different. In this species, the lavender phenotype is associated with a non-lethal complex mutation involving three consecutive overlapping chromosomal changes (two inversions and one deletion) that have consequences on the genomic organization of four genes (MLPH and the neighbouring PRLH, RAB17 and LRRFIP1). The deletion of PRLH has no effect on the level of circulating prolactin. Lavender birds have lighter body weight, lower body temperature and increased feed consumption and residual feed intake than wild-type plumage quail, indicating that this complex mutation is affecting the metabolism and the regulation of homeothermy. An extensive overlapping chromosome rearrangement was associated with a non-pathological Mendelian trait and minor, non deleterious effects in the lavender Japanese quail which is a natural knockout for PRLH.
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影响因子：
5.2
作者：
Chakarov, N.;Boerner, M.;Krueger, O.
通讯作者：
Krueger, O.
DOI：
10.1196/annals.1327.064
发表时间：
2005-01-01
期刊：
TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY
影响因子：
--
作者：
Lagerström, MC;Fredriksson, R;Schiöth, HB
通讯作者：
Schiöth, HB
影响因子：
3.3
作者：
Herd, R. M.;Arthur, P. F.
通讯作者：
Arthur, P. F.
影响因子：
4.4
作者：
Minvielle，F.;Gourichon，D.;Riviere，S.
通讯作者：
Riviere，S.
DOI：
10.1051/animres:19960637
发表时间：
1996-01-01
期刊：
Annales de Zootechnie (Paris)
影响因子：
--
作者：
France, J.;Dijkstra, J.;Dhanoa, M. S.
通讯作者：
Dhanoa, M. S.