Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T).
Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T).
复制标题
通过 1H NMR 在相对较低的场强 (1.9 T) 下检测低氧血症期间的体内脑乳酸。
DOI：
10.1073/pnas.81.8.2517
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发表时间：
1984
影响因子：
11.1
通讯作者：
Prichard,JW
中科院分区：
文献类型：
--
作者：
Behar,KL;Rothman,DL;Shulman,RG;Petroff,OA;Prichard,JW
在磁场强度为1.89 t的较低条件下，利用1H NMR监测低氧血症和恢复过程中兔脑内乳酸的产生和清除，并在采集频谱的同时记录一系列常规生理变量，包括脑电图和心电图。在这种场强下获得的灵敏度和光谱分辨率应该适用于目前可用的大口径磁体中人脑病理生理学的研究。
1H NMR was used to monitor lactate production and clearance during hypoxemia and recovery in the rabbit brain at the relatively low magnetic-field strength of 1.89 T. An array of conventional physiological variables were recorded simultaneously with spectrum acquisition, including the electroencephalogram and electrocardiogram. The sensitivity and spectral resolution achieved at this field strength should be applicable to studies of human brain pathophysiology in the large-bore magnets now available.