quick-to-court, a Drosophila mutant with elevated levels of sexual behavior, is defective in a predicted coiled-coil protein.
quick-to-court, a Drosophila mutant with elevated levels of sexual behavior, is defective in a predicted coiled-coil protein.
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发表时间：
2000-04
期刊：
影响因子：
3.3
通讯作者：
P. Gaines;L. Tompkins;C. Woodard;J. Carlson
中科院分区：
文献类型：
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作者：
P. Gaines;L. Tompkins;C. Woodard;J. Carlson
值得注意的是，人们对驱动性行为的分子机制知之甚少。我们已经发现了一种新的基因，快速求偶（qtc），它的突变导致雄性表现出高水平的雄性求偶。qtc雄性还显示出一种新的表型：当被置于处女雌性面前时，它们异常迅速地开始开始求偶。qtc突变的特异性是惊人的，因为男性性行为的许多方面都是正常的。我们已经克隆了qtc基因，发现它编码一种预测的卷曲螺旋蛋白，并在嗅觉器官、中枢神经系统和男性生殖道中表达。
Remarkably little is known about the molecular mechanisms that drive sexual behavior. We have identified a new gene, quick-to-court (qtc), whose mutations cause males to show high levels of male-male courtship. qtc males also show a novel phenotype: when placed in the presence of a virgin female, they begin courtship abnormally quickly. qtc mutations are striking in their specificity, in that many aspects of male sexual behavior are normal. We have cloned the qtc gene and found that it encodes a predicted coiled-coil protein and is expressed in the olfactory organs, central nervous system, and male reproductive tract.