Elevated serum uric acid predicts impaired fasting glucose and type 2 diabetes only among Japanese women undergoing health checkups
Elevated serum uric acid predicts impaired fasting glucose and type 2 diabetes only among Japanese women undergoing health checkups
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DOI：
10.1016/j.diabet.2010.10.009
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发表时间：
2011-06-01
影响因子：
7.2
通讯作者：
Joh, T.
中科院分区：
文献类型：
--
作者：
Yamada, T.;Fukatsu, M.;Joh, T.
的目标。本研究评估血清尿酸升高是否可以预测接受健康检查的日本人的空腹血糖（IFG）受损和2型糖尿病（T2DM）。-在2000年和2005年，共有7114名男性和5529名女性参与了这项研究。在排除IFG和T2DM患者后，对6408名男性和5309名女性（平均年龄分别为48.4 +/- 10.2岁和50.0 +/- 9.1岁）进行了多重logistic回归分析，以确定2005年新诊断的IFG和T2DM的独立危险因素，调整了年龄、父母糖尿病史、体重指数（HMI）、血压升高或高血压、脂肪肝、高甘油三酯血症、饮酒和吸烟状况。IFG和T2DM的患病率，以及BMI、收缩压和舒张压、空腹血糖和甘油三酯的值，与血清尿酸四分位数相关，在两性中都显示出显著增加的趋势。2005年新诊断为IFG和2型糖尿病的男性为8.1%，女性为4.0%。使用多变量模型，血清尿酸最高四分位数和血清尿酸升高是独立的危险因素，但仅适用于女性。血清尿酸在男性中不是危险因素，临界值为4.8 mg/dL，女性最高四分位数的界限为7.0 mg/dL。血清尿酸升高仅在定期健康检查的日本妇女中预测IFG和T2DM。(C) 2010 Elsevier Masson SAS。版权所有。
Aim. - This study assessed whether or not elevated serum uric acid can predict impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM) in Japanese people undergoing health checkups.Methods. - Altogether, 7114 male and 5529 female participants in both 2000 and 2005 were targeted for the study. After excluding those with IFG and T2DM, multiple logistic-regression analyses of 6408 men and 5309 women-average ages 48.4 +/- 10.2 and 50.0 +/- 9.1 years, respectively-were performed to identify independent risk factors for newly diagnosed IFG and T2DM in 2005, after adjusting for age, parental history of diabetes, body mass index (HMI), elevated blood pressure or hypertension, fatty liver, hypertriglyceridaemia, alcohol consumption and smoking status.Results. - Prevalence rates for IFG and T2DM, and values for BMI, systolic and diastolic blood pressure, fasting blood glucose and triglycerides, showed significantly increasing trends in relation to serum uric acid quartiles in both genders. IFG and T2DM were newly diagnosed in 8.1% of men and 4.0% of women in 2005. Using multivariate models, the highest quartile of serum uric acid and increases in serum uric acid were independent risk factors, but only in women. Serum uric acid was not a risk factor in men when categorized by the cut-off values of 4.8 mg/dL, the limit for the highest quartile in women, and of 7.0 mg/dL.Conclusion. - Elevated serum uric acid predicted IFG and T2DM only in Japanese women undergoing regular health checkups. (C) 2010 Elsevier Masson SAS. All rights reserved.