Current techniques in wound healing modulation in glaucoma surgery.
Current techniques in wound healing modulation in glaucoma surgery.
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DOI：
10.1097/00055735-199604000-00005
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发表时间：
1996-04-01
影响因子：
3.7
通讯作者：
Migdal, C S
中科院分区：
文献类型：
--
作者：
Khaw, P T;Migdal, C S
伤口愈合反应是青光眼手术后最终眼内压的唯一最重要的决定因素。抗瘢痕形成剂的使用，特别是抗代谢物5-氟尿嘧啶和丝裂霉素C，在过去的十年中彻底改变了青光眼手术。随着认识到仅仅将眼内压降低到21 mm Hg以下是不够的，并且在所有接受青光眼手术的患者中应实现眼内压的最佳降低，该主题变得更加重要。然而，抗代谢物仍然有许多潜在的问题和副作用，其中一些可能会威胁视力。本综述集中在这一领域的最新出版物，确定了目前的“最先进的”，以期优化结果，并尽量减少对我们的青光眼患者在这个令人兴奋和具有挑战性的进展领域的副作用。
The wound healing response is the single most important determinant of the final intraocular pressure after glaucoma surgery. The use of antiscarring agents, particularly the antimetabolites 5-fluorouracil and mitomycin C, have revolutionized glaucoma surgery over the past decade. This subject has become more important with the realization that simply lowering the intraocular pressure to below 21 mm Hg is inadequate, and that optimal lowering of the intraocular pressure should be achieved in all patients undergoing surgery for glaucoma. However, the antimetabolites still have many potential problems and side effects, some of which are potentially sightthreatening. This review concentrates on the recent publications in this field that have determined the current "state of the art," with a view toward optimizing results and minimizing side effects for our patients with glaucoma in this exciting and challenging area of progress.