One hundred years of Drosophila cancer research: no longer in solitude
One hundred years of Drosophila cancer research: no longer in solitude
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DOI：
10.1242/dmm.039032
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发表时间：
2019-04-01
影响因子：
4.3
通讯作者：
Villegas, Santiago Nahuel
中科院分区：
文献类型：
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作者：
Villegas, Santiago Nahuel
1918年，当玛丽·斯塔克第一次描述果蝇（Drosophila melanogaster）体内存在肿瘤时，她有没有想过果蝇会成为建模和理解肿瘤发生的宝贵生物体？如果是这样的话，她会期望这个模型需要100年才能得到完全认可吗？这篇专题文章总结了果蝇学家在不同科学时期为将果蝇建立为癌症研究的有效模型所做的努力和取得的成就。
When Mary Stark first described the presence of tumours in the fruit fly Drosophila melanogaster in 1918, would she ever have imagined that flies would become an invaluable organism for modelling and understanding oncogenesis? And if so, would she have expected it to take 100 years for this model to be fully accredited? This Special Article summarises the efforts and achievements of Drosophilists to establish the fly as a valid model in cancer research through different scientific periods.