Sox9 is associated with two distinct patterning events during snake lung morphogenesis.
Sox9 is associated with two distinct patterning events during snake lung morphogenesis.
复制标题
Sox9 与蛇肺形态发生过程中的两个不同的模式事件相关。
DOI：
10.1016/j.ydbio.2023.11.006
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发表时间：
2024
影响因子：
2.7
通讯作者：
Cardoso,WellingtonV
中科院分区：
文献类型：
--
作者：
vanSoldt,BenjaminJ;Metscher,BrianD;Richardson,MichaelK;Cardoso,WellingtonV
允许物种适应不同陆地环境并导致身体形状和大小的巨大多样性的进化力量需要在器官发生期间获得模式形成的创新策略。一个极端的例子是蛇的内脏高度拉长。是什么样的发育模式策略使蛇能够克服身体的空间限制，以满足生理需求？在这里，我们表明，玉米蛇使用Sox 2-Sox 9发育工具包常见的其他物种，以产生和塑造肺在两个阶段。最初，在支气管芽的生长和伸长过程中，在初级肺芽的尖端发现低水平的Sox 9，而不驱动哺乳动物肺的特征性分支程序。随后，Sox 9诱导在形成放射状隔膜的广泛网络中重演，所述放射状隔膜沿着产生呼吸区的伸长的支气管芽出现。我们建议，这些都代表了关键的模式化事件的形成呼吸faveolar和非呼吸后室的蛇的肺。
The evolutionary forces that allowed species adaptation to different terrestrial environments and led to great diversity in body shape and size required acquisition of innovative strategies of pattern formation during organogenesis. An extreme example is the formation of highly elongated viscera in snakes. What developmental patterning strategies allowed to overcome the space constraints of the snake's body to meet physiological demands? Here we show that the corn snake uses a Sox2-Sox9 developmental tool kit common to other species to generate and shape the lung in two phases. Initially Sox9 was found at low levels at the tip of the primary lung bud during outgrowth and elongation of the bronchial bud, without driving branching programs characteristic of mammalian lungs. Later, Sox9 induction is recapitulated in the formation of an extensive network of radial septae emerging along the elongated bronchial bud that generates the respiratory region. We propose that altogether these represent key patterning events for formation of both the respiratory faveolar and non-respiratory posterior compartments of the snake's lung.