COLONIC HYPERPLASIA AND HYPERPROLIFERATION INDUCED BY A NUTRITIONAL STRESS DIET WITH 4 COMPONENTS OF WESTERN-STYLE DIET
COLONIC HYPERPLASIA AND HYPERPROLIFERATION INDUCED BY A NUTRITIONAL STRESS DIET WITH 4 COMPONENTS OF WESTERN-STYLE DIET
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DOI：
10.1093/jnci/82.6.491
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发表时间：
1990-03-21
影响因子：
10.3
通讯作者：
MAHESHWARI, N
中科院分区：
文献类型：
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作者：
NEWMARK, HL;LIPKIN, M;MAHESHWARI, N
我们研究了特定营养修饰对小鼠和大鼠结肠上皮细胞增殖的影响。为本研究开发的营养应激饮食是基于美国营养学会(American Institute of Nutrition)-76A半合成饮食，修改后包含了人类西式饮食的四个风险因素：脂肪和磷酸盐增加，钙和维生素D含量减少。我们从3周龄开始给小鼠和大鼠喂食12周的饲料。小鼠和大鼠乙状结肠和升结肠均出现增生，结肠隐窝延长。小鼠和大鼠乙状结肠以及大鼠升结肠均出现增生，上皮细胞的[3H]胸腺嘧啶标记增加。因此，在结肠粘膜中，营养应激饮食（包括西式饮食的危险因素）在致癌诱导的啮齿动物模型和结肠肿瘤风险增加的人类中引起了变化。
We studied the effects of specific nutritional modifications on colonic epithelial cell proliferation in mice and rats. The nutritional stress diet developed for this study was based on the AIN (American Institute of Nutrition)-76A semisynthetic diet, modified to contain four suggested risk factors of the human Western-style diet: increased fat and phosphate and decreased calcium and vitamin D content. We fed diets to mice and rats for 12 weeks beginning at 3 weeks of age. Hyperplasia developed in both sigmoid and ascending colon of mice and rats with lengthening of colonic crypts. Hyperproliferation developed in the sigmoid colon of mice and rats, and in the ascending colon of rats, with increased [3H]thymidine-labeling of epithelial cells. Thus, in colonic mucosa, the nutritional stress diet, which included risk factors of a Western-style diet, induced changes that occur in carcinogen-induced rodent models and in humans who are at increased risk for colonic neoplasia.