Comparison of Magnetic Resonance Elastography and Gadoxetate Disodium-Enhanced Magnetic Resonance Imaging for the Evaluation of Hepatic Fibrosis
Comparison of Magnetic Resonance Elastography and Gadoxetate Disodium-Enhanced Magnetic Resonance Imaging for the Evaluation of Hepatic Fibrosis
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DOI：
10.1097/rli.0b013e318289ff8f
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发表时间：
2013-08-01
影响因子：
6.7
通讯作者：
Choi, Byung Ihn
中科院分区：
文献类型：
--
作者：
Choi, Ye Ra;Lee, Jeong Min;Choi, Byung Ihn
目的：本研究的目的是比较磁共振弹性成像（MRE）和钆塞酸二钠增强磁共振成像（MRI）在肝纤维化（HF）分期的肝脏疾病patients with liver diseases.Materials and Methods：这项回顾性研究是由我们的机构审查委员会批准，并放弃了知情同意。168例慢性肝病或疑似肝局灶性病变患者在1.5 T下接受了MRE和钆塞酸二钠增强MRI。在定量剪切刚度图上测量肝脏刚度值。对比增强指数（CEI）计算为SIpost / SIpre，其中SIpost和SIpre分别是肝胆相位图像和未增强图像上的肝脏与肌肉信号强度（SI）比。结果：MRE测量的肝硬度值（r = 0.802; P < 0.0001）与HF分期的相关性强于CEI（r = -0.378; P <0.0001）。肝硬度值的受试者工作特征曲线下的面积显著大于CEI用于区分HF所有阶段的受试者工作特征曲线下的面积（P < 0.001 for >= F1、>= F2、>= F3和>= F4）。磁共振弹性成像显示预测HF >= F1的敏感性和特异性更高（91%和87%），>= F2（87%和91%），>= F3（80%和89%），以及F4（81%和85%）与CEI相比结论：磁共振弹性成像对心力衰竭的分期具有上级的优势。
Objectives: The objective of this study was to compare the diagnostic performance of magnetic resonance elastography (MRE) and gadoxetate disodium-enhanced magnetic resonance imaging (MRI) in the staging of hepatic fibrosis (HF) in patients with liver diseases.Materials and Methods: This retrospective study was approved by our institutional review board, and the informed consent was waived. One hundred and sixty-eight patients with chronic liver disease or suspected focal hepatic lesions underwent MRE and gadoxetate disodium-enhanced MRI at 1.5 T. Liver stiffness values were measured on quantitative shear-stiffness maps. The contrast enhancement index (CEI) was calculated as SIpost / SIpre, where SIpost and SIpre are, respectively, the liver-to-muscle signal intensity (SI) ratio on hepatobiliary phase images and on unenhanced images. The diagnostic performance of MRE and CEI for staging HF was compared using the receiver operating characteristic curve analysis on the basis of the histopathologic analysis of HF.Results: The liver stiffness values measured on MRE (r = 0.802; P < 0.0001) were more strongly correlated with the HF stage than with the CEI (r = -0.378; P < 0.0001). The areas under the receiver operating characteristic curve values of the liver stiffness values were significantly larger than those of CEI were for discriminating all stages of HF (P < 0.001 for >= F1, >= F2, >= F3, and >= F4). Magnetic resonance elastography showed higher sensitivity and specificity for predicting HF >= F1 (91% and 87%), >= F2 (87% and 91%), >= F3 (80% and 89%), and F4 (81% and 85%) compared with CEI (46% and 85%, 46% and 82%, 63% and 68%, and 76% and 65%, respectively).Conclusions: Magnetic resonance elastography was superior to the gadoxetate disodium-enhancement MRI for HF staging.