Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Shedding and Predictors of Viral Culture Positivity on Vaccinated Healthcare Workers With Mild Coronavirus Disease 2019
Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Shedding and Predictors of Viral Culture Positivity on Vaccinated Healthcare Workers With Mild Coronavirus Disease 2019
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DOI：
10.1093/infdis/jiac391
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发表时间：
2022-09-22
影响因子：
6.4
通讯作者：
Costa, Silvia F.
中科院分区：
文献类型：
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作者：
Luna-Muschi, Alessandra;Noguera, Saidy Vasconez;Costa, Silvia F.
我们评估了病毒培养阳性的持续时间相比，快速抗原检测（RAT）和实时逆转录聚合酶链反应（RT-PCR）在轻度Omicron感染。接种疫苗的人可能在第7天内传播。RAT和RT-PCR是病毒培养阳性的预测因子。在这一前瞻性队列中，30名接种疫苗的医护人员轻度Omicron变异体感染，我们评估了病毒培养，快速抗原检测（RAT）和实时逆转录聚合酶链反应（RT-PCR）的呼吸道样本在第5，7，10和14天。在第5天和第7天，分别有46%（11/24）和20%（6/30）的样本病毒培养呈阳性。RAT和RT-PCR（Ct
We evaluated the duration of viral culture positivity compared to rapid antigen test (RAT) and real-time reverse-transcription polymerase chain reaction (RT-PCR) in mild Omicron infection. Vaccinated persons are potentially transmissible up to day 7. RAT and RT-PCR are predictors of viral culture positivity.In this prospective cohort of 30 vaccinated healthcare workers with mild Omicron variant infection, we evaluated viral culture, rapid antigen test (RAT), and real-time reverse-transcription polymerase chain reaction (RT-PCR) of respiratory samples at days 5, 7, 10, and 14. Viral culture was positive in 46% (11/24) and 20% (6/30) of samples at days 5 and 7, respectively. RAT and RT-PCR (Ct