Enhanced learning in mice parallels vector-mediated nerve growth factor expression in hippocampus.
Enhanced learning in mice parallels vector-mediated nerve growth factor expression in hippocampus.
复制标题
小鼠学习能力的增强与海马体中载体介导的神经生长因子的表达相似。
DOI：
10.1089/104303400750038453
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Federoff,HJ
中科院分区：
文献类型：
--
作者：
Brooks,AI;Cory-Slechta,DA;Bowers,WJ;Murg,SL;Federoff,HJ
Spatial learning requires the integrity of the nerve growth factor (NGF)-responsive septohippocampal pathway. Loss of a single NGF allele at the mouse NGF locus (heterozygous null,ngf+/-) reduces septohippocampal NGF levels and NGF-regulated cholinergic neurotransmitter enzymes and results in spatial learning deficits in adult animals. A herpes simplex virus (HSV) amplicon vector was utilized to locally deliver NGF to the hippocampus of mice heterozygous and wild type (ngf+/+) at the NGF gene locus. NGF gene transfer produced transient increases in NGF protein levels and choline acetyltransferase activity in bothngf+/-andngf+/+mice. However, spatial learning capability was improved only inngf+/-mice. In aggregate, these findings suggest that amplicon-directed expression of NGF in subjects with baseline septohippocampal dysfunction can correct spatial learning deficits.
