GB Virus C Coinfections in West African Ebola Patients
GB Virus C Coinfections in West African Ebola Patients
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DOI：
10.1128/jvi.02752-14
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发表时间：
2015-02-01
影响因子：
5.4
通讯作者：
O'Connor, David H.
中科院分区：
文献类型：
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作者：
Lauck, Michael;Bailey, Adam L.;O'Connor, David H.
在塞拉利昂持续爆发的埃博拉病毒疾病期间，49名已知埃博拉病毒疾病结果的患者中，有13人同时感染了免疫调节性佩吉病毒GB病毒C（GBV-C）。这些GBV-C+患者中有53%存活;相比之下，只有22%的GBV-C-患者存活。生存率和GBV-C状态均与年龄相关，老年患者的生存率较低，中年患者（21至45岁）的GBV-C感染率最高。了解GBV-C和年龄对埃博拉病毒存活的单独和综合影响可能会导致新的治疗和预防策略，也许是通过与年龄相关的免疫激活途径。
In 49 patients with known Ebola virus disease outcomes during the ongoing outbreak in Sierra Leone, 13 were coinfected with the immunomodulatory pegivirus GB virus C (GBV-C). Fifty-three percent of these GBV-C+ patients survived; in contrast, only 22% of GBV-C- patients survived. Both survival and GBV-C status were associated with age, with older patients having lower survival rates and intermediate-age patients (21 to 45 years) having the highest rate of GBV-C infection. Understanding the separate and combined effects of GBV-C and age on Ebola virus survival may lead to new treatment and prevention strategies, perhaps through age-related pathways of immune activation.