Activation of the mesostriatal reward pathway with exposure to ultraviolet radiation (UVR) vs. sham UVR in frequent tanners: a pilot study
Activation of the mesostriatal reward pathway with exposure to ultraviolet radiation (UVR) vs. sham UVR in frequent tanners: a pilot study
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DOI：
10.1111/j.1369-1600.2010.00312.x
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发表时间：
2012-05-01
影响因子：
3.4
通讯作者：
Adinoff, Bryon
中科院分区：
文献类型：
--
作者：
Harrington, Cynthia R.;Beswick, Tracy C.;Adinoff, Bryon
尽管人们越来越了解晒黑的相关发病率和死亡率，但频繁和过度的晒黑现象仍然存在，这表明紫外线辐射可能会带来超出假定的美容益处的有益效果。为了凭经验测量紫外线辐射 (UVR) 假定的中枢有益特性，我们使用单光子发射计算机断层扫描 (SPECT) 评估了市售晒黑床对局部脑血流量 (rCBF) 的影响，rCBF 是大脑活动的测量指标。七名经常在沙龙床上晒黑的人在两次疗程中被置于 UVA/UVB 晒黑灯下；一次使用 UVR，另一次使用过滤 UVR（假 UVR）。会议顺序是随机的，受试者对研究顺序不知情。在 UVR 期间，相对于假 UVR 期间，受试者表现出背侧纹状体、前岛叶和内侧眶额皮质（与奖励体验相关的大脑区域）的 rCBF 相对增加。这些变化伴随着晒黑的主观愿望的减少。这些发现表明，紫外线可能具有促进过度晒黑的集中奖励特性。
Frequent and excessive tanning persists despite a growing understanding of its associated morbidity and mortality, suggesting that ultraviolet radiation may impart rewarding effects beyond the assumed cosmetic benefits. To empirically measure putative centrally rewarding properties of ultraviolet radiation (UVR), we assessed the effects of a commercially available tanning bed upon regional cerebral blood flow (rCBF), a measure of brain activity, using single-photon emission computed tomography (SPECT). Seven frequent salon bed tanners were placed under a UVA/UVB tanning light during two sessions; one session with UVR and the other with filtered UVR (sham UVR). Session order was randomized and subjects were blinded to study order. During the UVR session, relative to sham UVR session, subjects demonstrated a relative increase in rCBF of the dorsal striatum, anterior insula and medial orbitofrontal cortex, brain regions associated with the experience of reward. These changes were accompanied by a decrease in the subjective desire to tan. These findings suggest that UVR may have centrally rewarding properties that encourage excessive tanning.