Complete Genome Sequence of a Novel Newcastle Disease Virus Strain Isolated from a Chicken in West Africa
Complete Genome Sequence of a Novel Newcastle Disease Virus Strain Isolated from a Chicken in West Africa
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DOI：
10.1128/jvi.01922-12
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发表时间：
2012-10-01
影响因子：
5.4
通讯作者：
Samal, Siba K.
中科院分区：
文献类型：
--
作者：
Kim, Shin-Hee;Nayak, Subhashree;Samal, Siba K.
测定了2009年从多哥一只鸡身上分离的一株非洲新城疫病毒(NDV)的全基因组序列。基因组长度为15,198个核苷酸(NT)，被归类为II类簇中的基因vii。与普通疫苗毒株相比，非洲毒株在N基因下游非翻译区包含一个先前描述的6-nT插入片段，在HN-L基因间隔区包含一个新的6-nT插入片段。基因组长度差异是新城疫病毒自然历史的标志。这是新城疫病毒第二类毒株的首次描述，该毒株基因组长15,198个核苷酸，在HN-L基因间隔区插入了一个6-核苷酸。相对于疫苗毒株的序列差异很大，很可能是暴发的原因，并说明了新的新城疫病毒毒株在西非的持续进化。
The complete genome sequence of an African Newcastle disease virus (NDV) strain isolated from a chicken in Togo in 2009 was determined. The genome is 15,198 nucleotides (nt) in length and is classified in genotype VII in the class II cluster. Compared to common vaccine strains, the African strain contains a previously described 6-nt insert in the downstream untranslated region of the N gene and a novel 6-nt insert in the HN-L intergenic region. Genome length differences are a marker of the natural history of NDV. This is the first description of a class II NDV strain with a genome of 15,198 nt and a 6-nt insert in the HN-L intergenic region. Sequence divergence relative to vaccine strains was substantial, likely contributes to outbreaks, and illustrates the continued evolution of new NDV strains in West Africa.