Effect of donor Langerhans cells on corneal graft rejection.
Effect of donor Langerhans cells on corneal graft rejection.
复制标题
供体朗格汉斯细胞对角膜移植排斥反应的影响。
DOI：
10.1111/1523-1747.ep12669985
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
He,Y
中科院分区：
文献类型：
--
作者：
Niederkorn,JY;Ross,JR;He,Y
与其他皮肤表面不同，角膜上皮的中心部分通常没有朗格汉斯细胞。中央角膜中 Ia+朗格汉斯细胞的缺乏不仅仅是偶然的兴趣，并且可以解释角膜同种异体移植物特征的免疫特权。本通讯总结了先前的研究，这些研究检查了角膜朗格汉斯细胞在引起啮齿动物同种免疫反应和角膜移植排斥中的作用。在正常情况下，玉米粉同种异体移植物在无血管眼移植床中的免疫原性很差，即使移植物显示出大量的同种异体抗原。免疫反应的传入阻断可以通过供体来源的朗格汉斯细胞来规避，朗格汉斯细胞作为所有类别的角膜同种异体移植物的有效免疫原，除了仅在 I 类主要组织相容性复合体位点涉及异体差异的移植物之外。因此，供体来源的朗格汉斯细胞的存在对同种异体角膜移植物的命运产生深远的影响。
Unlike other cutaneous surfaces, the central portion of the corneal epithelium is typically devoid of Langerhans cells. The absence of Ia+Langerhans cells in the central cornea is of more than casual interest and may explain the immunologic privilege that is characteristic of corneal allografts. The present communication, summarizes previous studies that examined the role of corneal Langerhans cells in eliciting alloimmune responses and corneal graft rejection in rodents. Under normal circumstances, cornmeal allografts are poorly immunogenic when residing in the avascular ocular graft bed even though the graft displays large quantities of alloantigens. The afferent blockade of the immune response can be circumvented by donor-derived Langerhans cells that serve as potent immunogens for all categories of corneal allografts except grafts involving allodisparity only at class I major histocompatibility complex loci. Thus, the presence of donor-derived Langerhans cells exerts profound effects on the fate of corneal allografts.