Insulin-induced anestrus in Syrian hamsters.
Insulin-induced anestrus in Syrian hamsters.
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胰岛素诱导的叙利亚仓鼠不发情。
DOI：
10.1152/ajpregu.1991.260.1.r148
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Friedman,MI
中科院分区：
文献类型：
--
作者：
Wade,GN;Schneider,JE;Friedman,MI
在叙利亚仓鼠中，繁殖对代谢燃料的可用性很敏感。发情周期可以被短暂的食物剥夺、糖酵解和脂肪酸氧化的药物抑制或体温调节所需的能量增加所中断。我们预测，将过量的代谢燃料供应转移到储存中的操作也会抑制繁殖。通过鱼精蛋白锌胰岛素悬浮液（PZI）处理，实现了代谢燃料从氧化到储存的重定向。接受PZI治疗并随意喂食的叙利亚仓鼠的食物摄入量增加了约40%，并储存了体脂，但对动情周期没有影响。当PZI处理的仓鼠限制在约等于注射前食物摄入量的110%时，它们仍然会发胖，并且对动情周期有显着抑制。因此，在没有暴饮暴食的情况下，PZI增强的能量储存可能导致可氧化代谢燃料的短缺，结果是生殖被抑制，有利于生存所必需的过程（例如，细胞维持、体温调节）。胰岛素诱导的乏情不太可能是由于PZI与代谢燃料分配无关的作用，因为该激素对自由采食仓鼠的发情周期没有影响。这些发现与营养性不孕是由于未能维持最低体脂含量的假设不一致，并提高了与某些类型的肥胖相关的不孕可能部分是由于大量营养素分配紊乱的可能性。
In Syrian hamsters, reproduction is sensitive to the availability of metabolic fuels. Estrous cycles can be interrupted by brief periods of food deprivation, by pharmacological inhibition of glycolysis and fatty acid oxidation, or by increasing energy demands for thermoregulation. We predicted that manipulations that divert an excessive portion of the metabolic fuel supply into storage also should inhibit reproduction. Redirection of metabolic fuels from oxidation to storage was accomplished by treatment with protamine zinc insulin suspension (PZI). Syrian hamsters treated with PZI and fed ad libitum increased their food intake by approximately equal to 40% and body fat stores, but there was no effect on estrous cycles. When PZI-treated hamsters were limited to approximately equal to 110% of their preinjection food intake, they still fattened, and there was a significant inhibition of estrous cyclicity. Thus, in the absence of overeating, PZI-enhanced energy storage may lead to a shortage of oxidizable metabolic fuels with the result that reproduction is inhibited in favor of processes essential for survival (e.g., cellular maintenance, thermoregulation). It is unlikely that insulin-induced anestrus is due to actions of PZI unrelated to metabolic fuel partitioning, because the hormone had no effects on estrous cyclicity in ad libitum-fed hamsters. These findings are inconsistent with the hypothesis that nutritional infertility is due to the failure to maintain a minimum body fat content and raise the possibility that the infertility associated with some types of obesity could be due in part to a disorder of macronutrient partitioning.