Advances in pharmacological interventions of aging in mice
Advances in pharmacological interventions of aging in mice
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小鼠衰老的药物干预研究进展
DOI：
10.1016/j.tma.2019.11.002
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发表时间：
2019
影响因子：
--
通讯作者：
Baohua Liu
中科院分区：
文献类型：
--
作者：
Minxian Qian;Baohua Liu
衰老研究的重大突破为我们探索潜在的干预措施以减缓衰老过程铺平了道路，更重要的是，改善健康状况。多种方法，包括药理学和非药理学干预措施（例如热量限制，体育锻炼），在很大程度上成功地解决了跨物种的年龄相关表型缺陷的挑战。到目前为止，分子化合物大量涌现，如热量限制模拟物，NAD+助推器和senolytics。作为最好的工具之一，小鼠模型的使用是必不可少的，以评估分子抗衰老的潜力，并为治疗人类虚弱提供转化基础。在这里，我们简要概述了目前在实验室小鼠模型中抗衰老治疗干预的进展，并讨论了其在人类抗衰老和衰老相关病理学临床应用中的益处和陷阱。
The remarkable breakthroughs in aging research pave the way allowing us to explore potential interventions to slow down aging process, and more importantly, to improve healthiness. Multiple approaches, including pharmacological and non-pharmacological interventions (e.g. caloric restriction, physical exercise), to a great extent, successfully tackle challenges of age-related phenotypic deficits across species. To date, molecular compounds are largely emerging, such as caloric restriction mimetics, NAD+boosters, and senolytics. The use of mouse models is essential, as one of the best tools, to evaluate the potentials of molecules against aging and to provide a translational basis for treating human frailty. Here, we briefly overview present advances on therapeutic interventions against aging in laboratory mouse models and discuss the benefits and pitfalls on their clinical application for anti-aging and aging-related pathologies in humans.