Dieting behaviors and risk of neural tube defects
Dieting behaviors and risk of neural tube defects
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DOI：
10.1093/aje/kwg286
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发表时间：
2003-12-15
影响因子：
5
通讯作者：
Selvin, S
中科院分区：
文献类型：
--
作者：
Carmichael, SL;Shaw, GM;Selvin, S
作者使用基于人群的病例对照数据研究了母亲节食行为是否与后代神经管缺陷（NTD）风险增加有关。该分析包括1989年至1991年在选定的加州县分娩的538例病例和539例非畸形对照，并通过亲自访问母亲来评估暴露情况。在四个报告的节食行为，包括限制食物摄入量，饮食减肥，（比值比= 2.1，95%置信区间：1.1，4.1），空腹饮食（比值比= 5.8，95%置信区间：1.7，20.0），进食障碍（比值比= 1.7，95%可信区间：0.8，3.6）与妊娠早期NTD风险增加相关。在怀孕前3个月，这些行为的风险估计值倾向于接近1。第四种行为，“其他特殊饮食”，在这两个时期都与NTD风险增加无关。妇女还报告了她们是否服用减肥药、泻药或利尿剂，是否暴饮暴食，是否诱发呕吐，是否从怀孕前3个月到怀孕结束过度运动。只有利尿剂的摄入与NTD风险的显著增加相关（比值比= 2.7，95%置信区间：0.7，10.2）。这项研究表明，母亲的饮食行为，包括限制食物摄入量在怀孕的头三个月可能与NTD的风险增加。
The authors examined whether maternal dieting behaviors were associated with increased neural tube defect (NTD) risk among offspring, using population-based, case-control data. The analysis included 538 cases and 539 nonmalformed controls delivered from 1989 to 1991 in selected California counties, and exposures were assessed by in-person maternal interview. Among four reported dieting behaviors involving restricted food intake, diets to lose weight (odds ratio = 2.1, 95% confidence interval: 1.1, 4.1), fasting diets (odds ratio = 5.8, 95% confidence interval: 1.7, 20.0), and eating disorders (odds ratio = 1.7, 95% confidence interval: 0.8, 3.6) were associated with increased NTD risk during the first trimester of pregnancy. Risk estimates for these behaviors during the 3 months before conception tended to be closer to 1. The fourth behavior, "other special diets," was not associated with increased NTD risk during either period. Women also reported whether they took diet pills, laxatives, or diuretics, engaged in binge eating, induced vomiting, or exercised excessively from the first 3 months before conception through the end of pregnancy. Only the intake of diuretics was associated with substantially increased NTD risk (odds ratio = 2.7, 95% confidence interval: 0.7, 10.2). This study suggests that maternal dieting behaviors involving restricted food intake during the first trimester may be associated with increased NTD risk.