Pharmacological Treatment of Agoraphobia
Pharmacological Treatment of Agoraphobia
复制标题
广场恐惧症的药物治疗
DOI：
10.1192/bjp.143.4.348
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发表时间：
1983
影响因子：
10.5
通讯作者：
R. Dealy
中科院分区：
文献类型：
--
作者：
M. Mavissakalian;L. Michelson;R. Dealy
总结18名广场恐怖症患者被随机分配到12周的丙咪嗪（I）或丙咪嗪和程序化的体内暴露实践（I +BT）治疗，以研究行为指导对药物治疗临床效果的贡献。与I组相比，在I +BT组中发现了对恐惧测量的显著更大改善。在恐慌和焦虑的测量上，差异不太明显。结果表明，丙咪嗪具有抗恐惧的效果，可以大大加强与程序化的做法。对广场恐怖症药物治疗的药理学和教学效果进行大规模的对照研究，是确定性地评价抗抑郁药物的特异性抗恐怖作用所必需的。
Summary Eighteen agoraphobic patients were randomly assigned to 12 week treatment with imipramine (I) or imipramine and programmed in-vivo exposure practice (l+BT) to investigate the contribution of behavioural instructions to the clinical effects of pharmacotherapy. Significantly greater improvement on phobic measures was found in the l+BT group compared to the I group. Differences were less marked on measures of panic and anxiety. The results suggest that imipramine possesses an antiphobic effect which can be substantially enhanced with programmed practice. Controlled large-scale investigations of the pharmacological and instructional effects of the pharmacotherapy of agoraphobia are needed for a definitive evaluation of the specific antiphobic effect of antidepressant drugs.
影响因子：
7.3
作者：
KLEIN, DF
通讯作者：
KLEIN, DF