Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation
Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation
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DOI：
10.1016/j.bbrc.2008.02.002
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发表时间：
2008-05-02
影响因子：
3.1
通讯作者：
Kawada, Teruo
中科院分区：
文献类型：
--
作者：
Kang, Min-Sook;Hirai, Shizuka;Kawada, Teruo
肥胖的特征在于巨噬细胞向脂肪组织的浸润增强，这与低度炎症状态和肥胖相关的病理学（如2型糖尿病和心血管疾病）密切相关。我们在这里表明，脱氢松香酸（DAA）是一种有效的过氧化物酶体增殖物激活受体α/γ双重激活剂。此外，我们研究了DAA在刺激的巨噬细胞和巨噬细胞和脂肪细胞的共培养物中的抗炎作用。DAA显著抑制了刺激的RAW 264巨噬细胞以及RAW 264巨噬细胞和3 T3-L1脂肪细胞的共培养物中促炎介质如MCP-1、TNF-α和NO的产生。这些结果表明，DAA是一种有价值的药物和食品成分，用于改善与肥胖相关的糖尿病相关的炎症变化。(c)2008年爱思唯尔公司All rights reserved.
Obesity is characterized by an enhanced infiltration of macrophages to adipose tissues, which is closely associated with the low-grade inflammatory state and obesity-related pathologies such as type 2 diabetes and cardiovascular diseases. We showed here that dehydroabietic acid (DAA) is a potent PPAR alpha/gamma dual activator. Furthermore, we examined the anti-inflammatory effects of DAA in stimulated macrophages and in the coculture of macrophages and adipocytes. DAA significantly suppressed the production of proinflammatory mediators such as MCP-1, TNF-alpha, and NO in stimulated RAW 264 macrophages and in the coculture of RAW 264 macrophages and 3T3-L1 adipocytes. These results suggest that DAA is a valuable medicinal and food component for improving inflammatory changes associated with obesity-related diabetes. (c) 2008 Elsevier Inc. All rights reserved.