Bile acid pattern in human amniotic fluid
Bile acid pattern in human amniotic fluid
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人羊水中的胆汁酸模式
DOI：
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发表时间：
1978
影响因子：
5.5
通讯作者：
D. Sidiropoulos
中科院分区：
文献类型：
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作者：
G. Délèze;G. Paumgartner;G. Karlaganis;W. Giger;M. Reinhard;D. Sidiropoulos
本文对26例妊娠32~41周的29例羊水标本进行了胆汁酸测定。总胆汁酸浓度范围为0.4~4.8μ/l，平均为1.5 7μ/L，除胆酸和鹅去氧胆酸外，共检出3种β-羟基-5-胆烯酸，10例为石胆酸，9例为脱氧胆酸。3妊娠32~37周β-羟基-5-胆汁酸占总胆汁酸的39.8%，足月占20.2%(P<；0.01)。这些发现指出胎儿和成人胆汁代谢的重要差异，并可能反映近期肝脏胆汁酸生物合成的成熟。
Abstract Individual bile acids were determined in twenty‐nine amniotic fluid specimens obtained from twenty‐six women between the 32nd and 41st week of gestation. Total bile acid concentration ranged from 0.4 to 4.8μmol/1 with a mean of 1.57μmol/l. Besides the two major bile acids of man, cholic acid and chenodeoxy‐cholic acid, 3β‐hydroxy‐5‐cholenoic acid was found in all, lithocholic acid in ten and deoxycholic acid in nine of the twenty‐nine amniotic fluid samples. 3β‐Hydroxy‐5‐cholenoic acid averaged 39.8% of total bile acids during 32–37 weeks of gestation and 20.2% at term (P<0.01). These findings point towards important differences between fetal and adult bile metabolism and may reflect maturation of hepatic bile acid biosynthesis near term.