Novel DPPH radical scavengers, bisorbicillinol and demethyltrichodimerol, from a fungus
Novel DPPH radical scavengers, bisorbicillinol and demethyltrichodimerol, from a fungus
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DOI：
10.1271/bbb.62.661
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发表时间：
1998-04-01
影响因子：
1.6
通讯作者：
Hirota, A
中科院分区：
文献类型：
--
作者：
Abe, N;Murata, T;Hirota, A
在我们筛选具有DPPH自由基清除活性的抗氧化剂的程序中，我们从从土壤样品中分离的木霉USF-2690菌株的发酵液中分离出四种黄色化合物：两种为新化合物，命名为bisorbicillinol（1）和dlemethyl dimerol（2），两种为已知化合物bisvertinolone（3）和dlemethyl dimerol（4）。化合物1和2的结构经光谱和化学修饰鉴定。两种化合物似乎是山梨西林的氧化二聚体。在DPPH自由基清除活性的评价中，在四种化合物中，bisorbicillinol给出最低的艾德，值（31.4 μ M），与BHT的值（27.0 μ M）相等。
In our screening program for antioxidants with DPPH radical scavenging activity, we isolated four yellowish compounds from the fermentation broth of Trichoderma sp. USF-2690 strain isolated from a soil sample: two were novel compounds designated bisorbicillinol (1) and dlemethyltrichodimerol (2), and two were known compounds bisvertinolone (3) and trichodimerol (4). The structures of 1 and 2 were elucidated by spectroscopic evidence and chemical modification. Two compounds seemed to be the oxidized dimers of sorbicillin. In the evaluation of DPPH radical scavenging activity, bisorbicillinol gave the lowest ED,, value (31.4 mu M) among the four compounds, equal to that of BHT (27.0 mu M).